Evidence map›Paper›PMID 36770909›Full record

ArticleMolecules (Basel, Switzerland)2023

Semisynthetic Sesquiterpene Lactones Generated by the Sensibility of Glaucolide B to Lewis and Brønsted-Lowry Acids and Bases: Cytotoxicity and Anti-Inflammatory Activities.

Layzon A Lemos da Silva, Louis P Sandjo, Laura S Assunção, Anne N Prigol, Carolina D de Siqueira, Tânia B Creczynski-Pasa, Marcus T Scotti, Luciana Scotti, Fabíola B Filippin-Monteiro, Maique W Biavatti

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Layzon A Lemos da SilvaPost-Graduate Program of Pharmacy, Universidade Federal de Santa Catarina, Campus Universitário-Trindade, Florianópolis CEP 8840-970, SC, Brazil.
Louis P SandjoDepartment of Chemistry, Universidade Federal de Santa Catarina, Campus Universitário-Trindade, Florianópolis CEP 88040-900, SC, Brazil.ORCID 0000-0001-5840-7733
Laura S AssunçãoPost-Graduate Program of Pharmacy, Universidade Federal de Santa Catarina, Campus Universitário-Trindade, Florianópolis CEP 8840-970, SC, Brazil.
Anne N PrigolPost-Graduate Program of Pharmacy, Universidade Federal de Santa Catarina, Campus Universitário-Trindade, Florianópolis CEP 8840-970, SC, Brazil.
Carolina D de SiqueiraPost-Graduate Program of Pharmacy, Universidade Federal de Santa Catarina, Campus Universitário-Trindade, Florianópolis CEP 8840-970, SC, Brazil.
Tânia B Creczynski-PasaDepartment of Pharmaceutical Sciences, Universidade Federal de Santa Catarina, Campus Universitário-Trindade, Florianópolis CEP 88040-970, SC, Brazil.
Marcus T ScottiPost-Graduate Program in Natural and Synthetic Bioactive Products, Universidade Federal da Paraíba, Cidade Universitária-Castelo Branco III, João Pessoa CEP 58051-900, PB, Brazil.ORCID 0000-0003-4863-8057
Luciana ScottiPost-Graduate Program in Natural and Synthetic Bioactive Products, Universidade Federal da Paraíba, Cidade Universitária-Castelo Branco III, João Pessoa CEP 58051-900, PB, Brazil.ORCID 0000-0003-1866-4107
Fabíola B Filippin-MonteiroDepartment of Clinical Analysis, Universidade Federal de Santa Catarina, Campus Universitário-Trindade, Florianópolis CEP 88040-900, SC, Brazil.ORCID 0000-0003-4313-1783
Maique W BiavattiDepartment of Pharmaceutical Sciences, Universidade Federal de Santa Catarina, Campus Universitário-Trindade, Florianópolis CEP 88040-970, SC, Brazil.
Universidade Federal de Santa Catarina · BRUniversidade Federal da Paraíba · BR

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 001
6 · The paper itself

Abstract

Sesquiterpene lactone (SL) subtypes including hirsutinolide and cadinanolide have a controversial genesis. Metabolites of these classes are either described as natural products or as artifacts produced via the influence of solvents, chromatographic mobile phases, and adsorbents used in phytochemical studies. Based on this divergence, and to better understand the sensibility of these metabolites, different pH conditions were used to prepare semisynthetic SLs and evaluate the anti-inflammatory and antiproliferative activities. Therefore, glaucolide B (

Indexed as

Antineoplastic AgentsSesquiterpenesAnti-Inflammatory AgentsHumansLactonesAnti-Inflammatory AgentsAntineoplastic Agentsglaucolide BLactonesSesquiterpenesanti-inflammatory activitycytotoxic activitysemisynthesissesquiterpene lactones

Identifiers

PMID36770909
PMCPMC9921329
OpenAlexW4318460145

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.