Evidence map›Paper›PMID 36770893›Full record

ArticleMolecules (Basel, Switzerland)2023

Neuroprotective Actions of Different Exogenous Nucleotides in H

Na Zhu, Riu Liu, Mei-Hong Xu, Yong Li

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Na ZhuDepartment of Nutrition and Food Hygiene, College of Public Health, Inner Mongolia Medical University, Hohhot 010059, China.
Riu LiuDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.
Mei-Hong XuDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.ORCID 0000-0001-7201-6982
Yong LiDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.ORCID 0000-0003-3914-5840

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exogenous nucleotides (NTs) are considered conditionally essential nutrients, and the brain cannot synthesize NTs de novo. Therefore, the external supplementation of exogenous NTs is of great significance for maintaining normal neuronal metabolism and function under certain conditions, such as brain aging. This study, therefore, sets out to assess the neuroprotective effect of four kinds of single exogenous NTs and a mixture of the NTs, and to elucidate the potential mechanism. A rat pheochromocytoma cell line PC-12 was treated with different concentrations of exogenous NTs after 4 h of exposure to 200 µM H

Indexed as

AntioxidantsNeuroprotective AgentsAnimalsCell DeathHydrogen PeroxideNADNeuroprotectionNucleotidesOxidative StressPC12 CellsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaRatsAntioxidantsHydrogen PeroxideNADNeuroprotective AgentsNucleotidesPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaexogenous nucleotidesinflammationmitochondrial functionneurodegenerativeneuroprotectiveoxidative stress

Identifiers

PMID36770893
PMCPMC9920452

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.