Evidence map›Paper›PMID 36770886›Full record

ArticleMolecules (Basel, Switzerland)2023

Potential Biological Properties of Lycopene in a Self-Emulsifying Drug Delivery System.

Sônia Nair Báo, Manuela Machado, Ana Luisa Da Silva, Adma Melo, Sara Cunha, Sérgio S Sousa, Ana Rita Malheiro, Rui Fernandes, José Roberto S A Leite, Andreanne G Vasconcelos and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sônia Nair BáoLaboratório de Microscopia e Microanálise, Departamento de Biologia Celular, Instituto de Ciências Biológicas, Universidade de Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, Brasília 70910-900, DF, Brazil.ORCID 0000-0002-9873-3098
Manuela MachadoCBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.
Ana Luisa Da SilvaLaboratório de Microscopia e Microanálise, Departamento de Biologia Celular, Instituto de Ciências Biológicas, Universidade de Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, Brasília 70910-900, DF, Brazil.
Adma MeloCBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.ORCID 0000-0002-9685-4689
Sara CunhaCBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.ORCID 0000-0003-1336-9993
Sérgio S SousaCBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.
Ana Rita Malheiroi3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.
Rui Fernandesi3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.ORCID 0000-0002-9535-368X
José Roberto S A LeiteNúcleo de Pesquisa em Morfologia e Imunologia Aplicada, Área de Morfologia, Faculdade de Medicina, Universidade de Brasília, UnB, Campus Universitário Darcy Ribeiro, Asa Norte, Brasília 70910-900, DF, Brazil.ORCID 0000-0002-1096-3236
Andreanne G VasconcelosNúcleo de Pesquisa em Morfologia e Imunologia Aplicada, Área de Morfologia, Faculdade de Medicina, Universidade de Brasília, UnB, Campus Universitário Darcy Ribeiro, Asa Norte, Brasília 70910-900, DF, Brazil.
João Relvasi3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.
Manuela PintadoCBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 0001Financiadora de Estudos e Projetos 01.08.0457.00Foundation for Research Support of the Federal District 128959/2021-69National Council for Scientific and Technological Development 303557/2021-4National Funds from FCT UIDB/50016/2020
6 · The paper itself

Abstract

In recent years, lycopene has been highlighted due to its antioxidant and anti-inflammatory properties, associated with a beneficial effect on human health. The aim of this study was to advance the studies of antioxidant and anti-inflammatory mechanisms on human keratinocytes cells (HaCaT) of a self-emulsifying drug delivery system (SEDDS) loaded with lycopene purified from red guava (nanoLPG). The characteristics of nanoLPG were a hydrodynamic diameter of 205 nm, a polydispersity index of 0.21 and a zeta potential of -20.57, providing physical stability for the nanosystem. NanoLPG demonstrated antioxidant capacity, as shown using the ORAC methodology, and prevented DNA degradation (DNA agarose). Proinflammatory activity was evaluated by quantifying the cytokines TNF-α, IL-6 and IL-8, with only IL-8 showing a significant increase (

Indexed as

AntioxidantsInterleukin-8Anti-Inflammatory AgentsDNADrug Delivery SystemsHumansLycopeneAnti-Inflammatory AgentsAntioxidantsDNAInterleukin-8Lycopeneantioxidantcarotenoidguava fruitnanomedicineskin care

Identifiers

PMID36770886
PMCPMC9920511

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.