Evidence map›Paper›PMID 36770883›Full record

ReviewMolecules (Basel, Switzerland)2023

Nanomaterials-Based Novel Immune Strategies in Clinical Translation for Cancer Therapy.

Shadma Wahab, Mohammed Ghazwani, Umme Hani, Abdulrahim R Hakami, Abdulrahman A Almehizia, Wasim Ahmad, Mohammad Zaki Ahmad, Prawez Alam, Sivakumar Annadurai

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Carbon Nanomaterials: Emerging Roles in Immuno-Oncology.International journal of molecular sciences · 2023
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shadma WahabDepartment of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia.ORCID 0000-0001-9941-2918
Mohammed GhazwaniDepartment of Pharmaceutics, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia.ORCID 0000-0003-3555-4268
Umme HaniDepartment of Pharmaceutics, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia.ORCID 0000-0003-4643-0922
Abdulrahim R HakamiDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha 61481, Saudi Arabia.ORCID 0000-0003-2101-8800
Abdulrahman A AlmehiziaDepartment of Pharmaceutical Chemistry, Drug Exploration and Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0001-8711-3873
Wasim AhmadDepartment of Pharmacy, Mohammed Al-Mana College for Medical Sciences, Dammam 34222, Saudi Arabia.ORCID 0000-0003-2639-9200
Mohammad Zaki AhmadDepartment of Pharmaceutics, College of Pharmacy, Najran University, Najran 11001, Saudi Arabia.ORCID 0000-0003-2979-8776
Prawez AlamDepartment of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.ORCID 0000-0002-7632-3426
Sivakumar AnnaduraiDepartment of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia.ORCID 0000-0001-7807-3742

Funding

King Khalid University RGP.1/343/43.
6 · The paper itself

Abstract

Immunotherapy shows a lot of promise for addressing the problems with traditional cancer treatments. Researchers and clinicians are working to create innovative immunological techniques for cancer detection and treatment that are more selective and have lower toxicity. An emerging field in cancer therapy, immunomodulation offers patients an alternate approach to treating cancer. These therapies use the host's natural defensive systems to identify and remove malignant cells in a targeted manner. Cancer treatment is now undergoing somewhat of a revolution due to recent developments in nanotechnology. Diverse nanomaterials (NMs) have been employed to overcome the limits of conventional anti-cancer treatments such as cytotoxic, surgery, radiation, and chemotherapy. Aside from that, NMs could interact with live cells and influence immune responses. In contrast, unexpected adverse effects such as necrosis, hypersensitivity, and inflammation might result from the immune system (IS)'s interaction with NMs. Therefore, to ensure the efficacy of immunomodulatory nanomaterials, it is essential to have a comprehensive understanding of the intricate interplay that exists between the IS and NMs. This review intends to present an overview of the current achievements, challenges, and improvements in using immunomodulatory nanomaterials (iNMs) for cancer therapy, with an emphasis on elucidating the mechanisms involved in the interaction between NMs and the immune system of the host.

Indexed as

Antineoplastic AgentsNanostructuresNeoplasmsHumansImmunotherapyNanotechnologyAntineoplastic Agentscancerimmunomodulationnanomaterialsphysicochemical parameters

Identifiers

PMID36770883
PMCPMC9920693

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.