Evidence map›Paper›PMID 36770873›Full record

ArticleMolecules (Basel, Switzerland)2023

New Succinimide-Thiazolidinedione Hybrids as Multitarget Antidiabetic Agents: Design, Synthesis, Bioevaluation, and Molecular Modelling Studies.

Mohammed A Huneif, Mater H Mahnashi, Muhammad Saeed Jan, Muhammad Shah, Sultan A Almedhesh, Seham M Alqahtani, Mohammad Jamaan Alzahrani, Muhammad Ayaz, Farhat Ullah, Umer Rashid and 1 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Assessment of the Biological Properties ofMolecules (Basel, Switzerland) · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Evaluation ofFrontiers in chemistry · 2024
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mohammed A HuneifPediatric Department, Medical College, Najran University, Najran 55461, Saudi Arabia.
Mater H MahnashiDepartment of Pharmaceutical Chemistry, College of Pharmacy, Najran University, Najran 55461, Saudi Arabia.ORCID 0000-0002-4837-3653
Muhammad Saeed JanDepartment of Pharmacy, Bacha Khan University, Charsadda 24461, Pakistan.ORCID 0000-0003-2411-6510
Muhammad ShahDepartment of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan.ORCID 0000-0002-1854-6365
Sultan A AlmedheshPediatric Department, Medical College, Najran University, Najran 55461, Saudi Arabia.
Seham M AlqahtaniPediatric Department, Medical College, Najran University, Najran 55461, Saudi Arabia.
Mohammad Jamaan AlzahraniPediatric Department, Medical College, Najran University, Najran 55461, Saudi Arabia.ORCID 0000-0001-6186-6076
Muhammad AyazDepartment of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara 18000, Pakistan.ORCID 0000-0002-4299-2445
Farhat UllahDepartment of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara 18000, Pakistan.ORCID 0000-0001-7907-0842
Umer RashidDepartment of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan.
Abdul SadiqDepartment of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara 18000, Pakistan.ORCID 0000-0002-0154-7863

Funding

Najran University NU/IF/ENT/01/010
6 · The paper itself

Abstract

Diabetes mellitus (DM) is a metabolic disorder majorly arising from the pathophysiology of the pancreas manifested as a decline in the insulin production or the tissue's resistance to the insulin. In this research, we have rationally designed and synthesized new succinimide-thiazolidinedione hybrids for the management of DM. In a multistep reaction, we were able to synthesize five new derivatives (

Indexed as

Diabetes MellitusThiazolidinedionesalpha-Amylasesalpha-GlucosidasesAnimalsDipeptidyl Peptidase 4Glycoside Hydrolase InhibitorsHypoglycemic AgentsInsulinMolecular Docking SimulationSuccinimidesalpha-Amylasesalpha-GlucosidasesDipeptidyl Peptidase 4Glycoside Hydrolase InhibitorsHypoglycemic AgentsInsulinSuccinimidesThiazolidinedionesantidiabeticDPP4 and molecular dockingPTP1Bsuccinimidethiazolidinedioneα-amylaseα-glucosidase

Identifiers

PMID36770873
PMCPMC9918900

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.