Evidence map›Paper›PMID 36770863›Full record

ArticleMolecules (Basel, Switzerland)2023

Synthesis and Antiproliferative Activity of Steroidal Diaryl Ethers.

Édua Kovács, Hazhmat Ali, Renáta Minorics, Péter Traj, Vivien Resch, Gábor Paragi, Bella Bruszel, István Zupkó, Erzsébet Mernyák

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Site-selective arylations of nature-inspired flavonoids or steroidal phenolsJournal of enzyme inhibition and medicinal chemistry · 2025
    Article
  2. Article
  3. Monofluoromethylation ofInternational journal of molecular sciences · 2023
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Édua KovácsDepartment of Organic Chemistry, University of Szeged, H-6720 Szeged, Hungary.
Hazhmat AliInstitute of Pharmacodynamics and Biopharmacy, University of Szeged, H-6720 Szeged, Hungary.ORCID 0000-0002-2553-8443
Renáta MinoricsInstitute of Pharmacodynamics and Biopharmacy, University of Szeged, H-6720 Szeged, Hungary.
Péter TrajDepartment of Organic Chemistry, University of Szeged, H-6720 Szeged, Hungary.
Vivien ReschDepartment of Medicinal Chemistry, University of Szeged, H-6720 Szeged, Hungary.
Gábor ParagiDepartment of Medicinal Chemistry, University of Szeged, H-6720 Szeged, Hungary.ORCID 0000-0001-5408-1748
Bella BruszelDepartment of Medicinal Chemistry, University of Szeged, H-6720 Szeged, Hungary.
István ZupkóInstitute of Pharmacodynamics and Biopharmacy, University of Szeged, H-6720 Szeged, Hungary.ORCID 0000-0003-3243-5300
Erzsébet MernyákDepartment of Organic Chemistry, University of Szeged, H-6720 Szeged, Hungary.

Funding

National Research, Development and Innovation Office 139323tkp2021-ega-17 tkp2021-ega-17
6 · The paper itself

Abstract

Novel 13α-estrone derivatives have been synthesized via direct arylation of the phenolic hydroxy function. Chan-Lam couplings of arylboronic acids with 13α-estrone as a nucleophilic partner were carried out under copper catalysis. The antiproliferative activities of the newly synthesized diaryl ethers against a panel of human cancer cell lines (A2780, MCF-7, MDA-MB 231, HeLa, SiHa) were investigated by means of MTT assays. The quinoline derivative displayed substantial antiproliferative activity against MCF-7 and HeLa cell lines with low micromolar IC

Indexed as

Antineoplastic AgentsOvarian NeoplasmsCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorEstroneEthersFemaleHeLa CellsHumansMolecular StructureStructure-Activity RelationshipTubulinAntineoplastic AgentsEstroneEthersTubulin13α-estroneantiproliferative effectChan–Lam reactiondiaryl ethermolecular dynamicstubulin polymerization

Identifiers

PMID36770863
PMCPMC9919549

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.