Evidence map›Paper›PMID 36770860›Full record

ArticleMolecules (Basel, Switzerland)2023

Establishment of LC-MS/MS Method for Determination of GMDTC in Rat Plasma and Its Application in Preclinical Pharmacokinetics.

Wei Hu, Zhi-Yong Zhong, Yu-Ting Gao, Xue-Feng Ren, Hai-Yang Liu, Xiao-Jiang Tang

Abstract read
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In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wei HuKey Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China.
Zhi-Yong ZhongJianersheng (Zhuhai) Pharmtech Co., Ltd., Zhuhai 519040, China.
Yu-Ting GaoJianersheng (Zhuhai) Pharmtech Co., Ltd., Zhuhai 519040, China.
Xue-Feng RenJianersheng (Zhuhai) Pharmtech Co., Ltd., Zhuhai 519040, China.
Hai-Yang LiuKey Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China.ORCID 0000-0002-1793-952X
Xiao-Jiang TangJianersheng (Zhuhai) Pharmtech Co., Ltd., Zhuhai 519040, China.

Funding

Guangdong Basic and Applied Basic Research Foundation 2021A1515010771National Natural Science Foundation of China 21671068; 81872571Support Scheme of Guangzhou for Leading Talents in Innovation an Entrepreneurship 2019013Zhuhai industry-university-research Cooperation Project ZH22017001210086PWC
6 · The paper itself

Abstract

Sodium (S)-2-(dithiocarboxylato((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)amino)-4(methylthio)butanoate (GMDTC) is the first compound to use cadmium repellent as an indication. In this paper, we established and validated a bioanalytical method for the determination of GMDTC in rat plasma, and used it to determine the drug concentrations in the plasma of rats after intravenous dosing in different genders and dosages. After pretreating the plasma samples with an acetonitrile-water-ammonia solution (70:30:1.25,

Indexed as

CadmiumTandem Mass SpectrometryAnimalsChromatography, High Pressure LiquidChromatography, LiquidFemaleIndicators and ReagentsMaleRatsReproducibility of ResultsCadmiumIndicators and Reagentsbioanalytical methodcadmiumGMDTCLC–MS/MSpharmacokinetic

Identifiers

PMID36770860
PMCPMC9919763

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.