Evidence map›Paper›PMID 36770828›Full record

ArticleMolecules (Basel, Switzerland)2023

Chloroquine-Based Mitochondrial ATP Inhibitors.

Zhiguo Wang, Robert J Sheaff, Syed R Hussaini

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zhiguo WangDepartment of Chemistry and Biochemistry, The University of Tulsa, 430 South Gary Place, Tulsa, OK 74104, USA.
Robert J SheaffDepartment of Chemistry and Biochemistry, The University of Tulsa, 430 South Gary Place, Tulsa, OK 74104, USA.
Syed R HussainiDepartment of Chemistry and Biochemistry, The University of Tulsa, 430 South Gary Place, Tulsa, OK 74104, USA.ORCID 0000-0002-5425-3332

Funding

Interdisciplinary Project Grant by The University of Tulsa The University of Tulsa
6 · The paper itself

Abstract

Mitochondria is an important drug target for ailments ranging from neoplastic to neurodegenerative diseases and metabolic diseases. Here, we describe the synthesis of chloroquine analogs and show the results of mitochondrial ATP inhibition testing. The 2,4-dinitrobenzene-based analogs showed concentration-dependent mitochondrial (mito.) ATP inhibition. The most potent mito. ATP inhibitor was found to be

Indexed as

ChloroquineMitochondriaAdenosine TriphosphateDrug Delivery SystemsAdenosine TriphosphateChloroquinechloroquinehydroxychloroquinemitochondrial inhibitor

Identifiers

PMID36770828
PMCPMC9920964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.