Evidence map›Paper›PMID 36770802›Full record

ArticleMolecules (Basel, Switzerland)2023

Design, Synthesis and Structure-Activity Relationship Studies of Nicotinamide Derivatives as Potent Antifungal Agents by Disrupting Cell Wall.

Tingjunhong Ni, Fei Xie, Liping Li, Yumeng Hao, Xiaochen Chi, Lan Yan, Dazhi Zhang, Yuanying Jiang, Quanzhen Lv

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Discovery of novel thiosemicarbazone derivatives with potent and selective anti-Journal of enzyme inhibition and medicinal chemistry · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tingjunhong NiDepartment of Pharmacy, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, No. 1239 Siping Road, Shanghai 200092, China.ORCID 0000-0002-6004-8116
Fei XieSchool of Pharmacy, Naval Medical University, No. 325 Guohe Road, Shanghai 200433, China.ORCID 0000-0002-0427-3802
Liping LiDepartment of Pharmacy, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, No. 1239 Siping Road, Shanghai 200092, China.
Yumeng HaoSchool of Pharmacy, Naval Medical University, No. 325 Guohe Road, Shanghai 200433, China.
Xiaochen ChiSchool of Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
Lan YanSchool of Pharmacy, Naval Medical University, No. 325 Guohe Road, Shanghai 200433, China.
Dazhi ZhangDepartment of Pharmacy, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, No. 1239 Siping Road, Shanghai 200092, China.
Yuanying JiangDepartment of Pharmacy, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, No. 1239 Siping Road, Shanghai 200092, China.
Quanzhen LvSchool of Pharmacy, Naval Medical University, No. 325 Guohe Road, Shanghai 200433, China.

Funding

Fundamental Research Funds for the Central Universities NO. 22120210587National Key Research and Development Program of China No. 2021YFC2300400National Natural Science Foundation of China No. 81830106National Natural Science Foundation of China No. 81902039National Natural Science Foundation of China No. 82020108032National Natural Science Foundation of China No. 82103991
6 · The paper itself

Abstract

Fungal infections pose a serious challenge to human health due to the limited paucity of antifungal treatments. Starting as a hit compound screened from our compound library, a series of nicotinamide derivatives have been successfully synthesized via a facile one-step coupling reaction of aromatic carboxylic acid and amine. The synthesized compounds were evaluated for their antifungal activity against

Indexed as

Antifungal AgentsNiacinamideCandida albicansFluconazoleHumansMicrobial Sensitivity TestsStructure-Activity RelationshipAntifungal AgentsFluconazoleNiacinamideantifungalhit-to-leadnicotinamidestructure-activity relationshipsynthesis

Identifiers

PMID36770802
PMCPMC9919825

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.