Evidence map›Paper›PMID 36770776›Full record

ReviewMolecules (Basel, Switzerland)2023

Construction of Smart Biomaterials for Promoting Diabetic Wound Healing.

Chan Huang, Weiyan Yuan, Jun Chen, Lin-Ping Wu, Tianhui You

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  11. Accelerated dermal wound healing in diabetic mice by a HJournal of materials chemistry. B · 2025
    Article
  12. Applications and prospects of biomaterials in diabetes management.Frontiers in bioengineering and biotechnology · 2025
    Review
  13. Article
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  19. Functional drug-delivery hydrogels for oral and maxillofacial wound healing.Frontiers in bioengineering and biotechnology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chan HuangSchool of Nursing, Guangdong Pharmaceutical University, Guangzhou 510006, China.ORCID 0000-0003-0063-3855
Weiyan YuanSchool of Nursing, Guangdong Pharmaceutical University, Guangzhou 510006, China.ORCID 0000-0003-1861-2286
Jun ChenDepartment of Organ Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China.
Lin-Ping WuCenter for Chemical Biology and Drug Discovery, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.ORCID 0000-0001-7579-2987
Tianhui YouCenter for Drug Research and Development, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, School of Nursing, Guangdong Pharmaceutical University, Guangzhou 510006, China.

Funding

Guangdong Pearl River Talents Program No. 2017GC010411International Science and Technology Cooperation Program of Guangdong Province No.2019A050510028National Key R&D Program of China No.2019YFA0110500Project of Educational Commission of Guangdong Province 2021KCXTD056
6 · The paper itself

Abstract

Diabetes mellitus is a complicated metabolic disease that has become one of the fastest-growing health crises in modern society. Diabetic patients may suffer from various complications, and diabetic foot is one of them. It can lead to increased rates of lower-extremity amputation and mortality, even seriously threatening the life and health of patients. Because its healing process is affected by various factors, its management and treatment are very challenging. To address these problems, smart biomaterials have been developed to expedite diabetic wound closure and improve treatment outcomes. This review begins with a discussion of the basic mechanisms of wound recovery and the limitations of current dressings used for diabetic wound healing. Then, the categories and characteristics of the smart biomaterial scaffolds, which can be utilized as a delivery system for drugs with anti-inflammatory activity, bioactive agency, and antibacterial nanoparticles for diabetic wound treatment were described. In addition, it can act as a responsive system to the stimulus of the pH, reactive oxygen species, and glucose concentration from the wound microenvironment. These results show that smart biomaterials have an enormous perspective for the treatment of diabetic wounds in all stages of healing. Finally, the advantages of the construction of smart biomaterials are summarized, and possible new strategies for the clinical management of diabetic wounds are proposed.

Indexed as

Diabetes MellitusDiabetic FootAnti-Bacterial AgentsBandagesBiocompatible MaterialsHumansWound HealingAnti-Bacterial AgentsBiocompatible Materialsbiological dressingsdiabetic foothydrogelregenerative medicinetissue engineeringwound healing

Identifiers

PMID36770776
PMCPMC9920261

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.