Evidence map›Paper›PMID 36770721›Full record

ArticleMolecules (Basel, Switzerland)2023

Development of a New Methodology for Dearomative Borylation of Coumarins and Chromenes and Its Applications to Synthesize Boron-Containing Retinoids.

Bhaskar C Das, Pratik Yadav, Sasmita Das, Mariko Saito, Todd Evans

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bhaskar C DasArnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201, USA.
Pratik YadavArnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201, USA.ORCID 0000-0002-4845-4189
Sasmita DasArnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201, USA.
Mariko SaitoNathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
Todd EvansDepartment of Surgery, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA.ORCID 0000-0002-7148-9849

Funding

Development of Novel MetAP2 inhibitors as potential therapeutics for MicrosporidiosisR01AI132614 · NIAID · LONG ISLAND UNIVERSITY BROOKLYN CAMPUS · PI DAS, BHASKAR CHANDRA, WEISS, LOUIS M. · 2018 to 2022
$2.5M
Targeting of Mitochondrial Lon Protease as a Novel Therapy for GlioblastomaR01NS109423 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI BOTA, DANIELA ANNENELIE, DAS, BHASKAR CHANDRA · 2020 to 2024
$2.3M
Receptor Specific Retinoids Probes to Study the Brain Damage Caused byDevelopmental Alcohol ExposureR21AA027374 · NIAAA · LONG ISLAND UNIVERSITY BROOKLYN CAMPUS · PI DAS, BHASKAR CHANDRA, SAITO, MARIKO · 2019 to 2020
$675k
NIAAA NIH HHS R21 AA027374NIAID NIH HHS R01 AI132614NIH HHS AA027374-01,R01AI132614-01A1,NINDS NIH HHS R01 NS109423
6 · The paper itself

Abstract

Dearomative borylation of coumarins and chromenes via conjugate addition represents a relatively unexplored and challenging task. To address this issue, herein, we report a new and general copper (I) catalyzed dearomative borylation process to synthesize boron-containing oxacycles. In this report, the borylation of coumarins, chromones, and chromenes comprising functional groups, such as esters, nitriles, carbonyls, and amides, has been achieved. In addition, the method generates different classes of potential boron-based retinoids, including the ones with oxadiazole and anthocyanin motifs. The borylated oxacycles can serve as suitable intermediates to generate a library of compounds.

Indexed as

BenzopyransBoronAmidesCopperCoumarinsAmidesBenzopyransBoronCopperCoumarinsborylationchromenesconjugate additioncoumarinsoxacyclesretinoinds

Identifiers

PMID36770721
PMCPMC9921500

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.