Evidence map›Paper›PMID 36770709›Full record

ArticleMolecules (Basel, Switzerland)2023

Antioxidant, Wound Healing Potential and In Silico Assessment of Naringin, Eicosane and Octacosane.

Abbirami Balachandran, Sy Bing Choi, Morak-Młodawska Beata, Jeleń Małgorzata, Gabriele R A Froemming, Charlie A Lavilla, Merell P Billacura, Stepfanie N Siyumbwa, Patrick N Okechukwu

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Effects of Dietary Supplementation withAnimals : an open access journal from MDPI · 2025
    Article
  6. Article
  7. The Pharmacological Potential ofInternational journal of molecular sciences · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Current drug discovery technologies · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. RSC advances · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Abbirami BalachandranDepartment of Biotechnology, Faculty of Applied Sciences, UCSI University, Cheras 56000, Kuala Lumpur, Malaysia.ORCID 0000-0003-4797-7022
Sy Bing ChoiDepartment of Biotechnology, Faculty of Applied Sciences, UCSI University, Cheras 56000, Kuala Lumpur, Malaysia.
Morak-Młodawska BeataFaculty of Pharmaceutical Sciences, Department of Organic Chemistry, Medical University of Sílesia, Jagiellonska, Str. 4, 41-200 Sosnowiec, Poland.ORCID 0000-0001-5389-1079
Jeleń MałgorzataFaculty of Pharmaceutical Sciences, Department of Organic Chemistry, Medical University of Sílesia, Jagiellonska, Str. 4, 41-200 Sosnowiec, Poland.ORCID 0000-0002-4144-990X
Gabriele R A FroemmingBasic Medical Sciences, Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak (UNIMAS), Kota Samarahan 94300, Sarawak, Malaysia.
Charlie A LavillaChemistry Department, College of Science & Mathematics, Mindanao State University-Iligan Institute of Technology, Iligan City 9200, Lanao del Norte, Philippines.ORCID 0000-0002-9832-1229
Merell P BillacuraDepartment of Chemistry, College of Natural Sciences and Mathematics, Mindanao State University-Main Campus, Marawi City 9700, Lanao del Sur, Philippines.ORCID 0000-0002-4398-8130
Stepfanie N SiyumbwaDepartment of Pathology and Microbiology, School of Medicine, Lusaka P.O. Box 50110, Zambia.ORCID 0000-0003-2726-1748
Patrick N OkechukwuDepartment of Biotechnology, Faculty of Applied Sciences, UCSI University, Cheras 56000, Kuala Lumpur, Malaysia.ORCID 0000-0002-3855-2666

Funding

Medical University of Silesia, Poland PCN-1-041/K/2/F and PCN-1-043/K/2/FUCSI University UCSI UNIVERSITY, REIG-FAS-2020/031
6 · The paper itself

Abstract

1. Diabetic chronic wounds, mainly foot ulcers, constitute one of the most common complications of poorly managed diabetes mellitus. The most typical reasons are insufficient glycemic management, latent neuropathy, peripheral vascular disease, and neglected foot care. In addition, it is a common cause of foot osteomyelitis and amputation of the lower extremities. Patients are admitted in larger numbers attributable to chronic wounds compared to any other diabetic disease. In the United States, diabetes is currently the most common cause of non-traumatic amputations. Approximately five percent of diabetics develop foot ulcers, and one percent require amputation. Therefore, it is necessary to identify sources of lead with wound-healing properties. Redox imbalance due to excessive oxidative stress is one of the causes for the development of diabetic wounds. Antioxidants have been shown to decrease the progression of diabetic neuropathy by scavenging ROS, regenerating endogenous and exogenous antioxidants, and reversing redox imbalance. Matrix metalloproteinases (MMPs) play vital roles in numerous phases of the wound healing process. Antioxidant and fibroblast cell migration activity of

Indexed as

Diabetic FootAlkanesAnimalsAntioxidantsCollagenFlavanonesHumansMatrix MetalloproteinasesMolecular Docking SimulationRatsWound HealingAlkanesAntioxidantsCollageneicosaneFlavanonesMatrix Metalloproteinasesnaringinoctacosaneantioxidantsdiabetes mellituseicosaneMMPsnaringinoctacosanewound healing

Identifiers

PMID36770709
PMCPMC9919607

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.