Evidence map›Paper›PMID 36770593›Full record

ArticleMolecules (Basel, Switzerland)2023

Design and Synthesis of New Modified Flexible Purine Bases as Potential Inhibitors of Human PNP.

Anastasia Khandazhinskaya, Ilja Fateev, Barbara Eletskaya, Anna Maslova, Irina Konstantinova, Katherine Seley-Radtke, Sergey Kochetkov, Elena Matyugina

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Anastasia KhandazhinskayaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.ORCID 0000-0003-1452-0253
Ilja FateevShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.ORCID 0000-0002-8571-4197
Barbara EletskayaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.ORCID 0000-0002-9552-7141
Anna MaslovaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Irina KonstantinovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Katherine Seley-RadtkeDepartment of Chemistry & Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.ORCID 0000-0002-0154-3459
Sergey KochetkovEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.ORCID 0000-0002-7443-6961
Elena MatyuginaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.ORCID 0000-0002-4981-7316
Engelhardt Institute of Molecular Biology · RUInstitute of Bioorganic Chemistry · RUUniversity of Maryland, Baltimore County · US

Funding

Russian Science Foundation 19-74-10048 (design and chemical synthesis) and 21-13-00429 (enzymatic studies)
6 · The paper itself

Abstract

The great interest in studying the structure of human purine nucleoside phosphorylase (

Indexed as

Escherichia coliPurine-Nucleoside PhosphorylaseEnzyme InhibitorsHumansNucleosidesPurinesEnzyme InhibitorsNucleosidesPurine-Nucleoside PhosphorylasePurinesaza/deazapurinesfleximer inhibitorhuman purine nucleoside phosphorylase

Identifiers

PMID36770593
PMCPMC9921493
OpenAlexW4317036521

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.