Evidence map›Paper›PMID 36770486›Full record

ReviewNanomaterials (Basel, Switzerland)2023

Nanomaterials for Molecular Detection and Analysis of Extracellular Vesicles.

Mitchell Lee Taylor, Anthony Gregory Giacalone, Kristopher Daniel Amrhein, Raymond Edward Wilson, Yongmei Wang, Xiaohua Huang

Abstract readReview
In one paragraph

Review in Nanomaterials (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mitchell Lee TaylorDepartment of Chemistry, The University of Memphis, Memphis, TN 38152, USA.
Anthony Gregory GiacaloneDepartment of Chemistry, The University of Memphis, Memphis, TN 38152, USA.
Kristopher Daniel AmrheinDepartment of Chemistry, The University of Memphis, Memphis, TN 38152, USA.
Raymond Edward WilsonDepartment of Chemistry, The University of Memphis, Memphis, TN 38152, USA.
Yongmei WangDepartment of Chemistry, The University of Memphis, Memphis, TN 38152, USA.ORCID 0000-0002-7418-9489
Xiaohua HuangDepartment of Chemistry, The University of Memphis, Memphis, TN 38152, USA.

Funding

Single exosome protein profiling with surface enhanced Raman scattering imagingR15CA238890 · NCI · UNIVERSITY OF MEMPHIS · PI HOANG, THANG BA, HUANG, XIAOHUA · 2020 to 2020
$416k
NCI NIH HHS R15 CA238890NIH HHS 1R15CA238890-01A1
6 · The paper itself

Abstract

Extracellular vesicles (EVs) have emerged as a novel resource of biomarkers for cancer and certain other diseases. Probing EVs in body fluids has become of major interest in the past decade in the development of a new-generation liquid biopsy for cancer diagnosis and monitoring. However, sensitive and specific molecular detection and analysis are challenging, due to the small size of EVs, low amount of antigens on individual EVs, and the complex biofluid matrix. Nanomaterials have been widely used in the technological development of protein and nucleic acid-based EV detection and analysis, owing to the unique structure and functional properties of materials at the nanometer scale. In this review, we summarize various nanomaterial-based analytical technologies for molecular EV detection and analysis. We discuss these technologies based on the major types of nanomaterials, including plasmonic, fluorescent, magnetic, organic, carbon-based, and certain other nanostructures. For each type of nanomaterial, functional properties are briefly described, followed by the applications of the nanomaterials for EV biomarker detection, profiling, and analysis in terms of detection mechanisms.

Indexed as

cancerdiagnosticsexosomeextracellular vesiclemolecular detectionnanomaterials

Identifiers

PMID36770486
PMCPMC9920192

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.