Evidence map›Paper›PMID 36770436›Full record

ArticleNanomaterials (Basel, Switzerland)2023

Nano-Conversion of Ineffective Cephalosporins into Potent One against Resistant Clinical Uro-Pathogens via Gold Nanoparticles.

Syed Mohd Danish Rizvi, Talib Hussain, Farhan Alshammari, Hana Sonbol, Nabeel Ahmad, Syed Shah Mohammed Faiyaz, Mohammad Amjad Kamal, El-Sayed Khafagy, Afrasim Moin, Amr Selim Abu Lila

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Emerging Field of Nanotechnology in Environment.Indian journal of microbiology · 2023
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Syed Mohd Danish RizviDepartment of Pharmaceutics, College of Pharmacy, University of Ha'il, Ha'il 81442, Saudi Arabia.ORCID 0000-0002-3106-4707
Talib HussainMolecular Diagnostic & Personalized Therapeutic Unit, University of Ha'il, Ha'il 81442, Saudi Arabia.
Farhan AlshammariDepartment of Pharmaceutics, College of Pharmacy, University of Ha'il, Ha'il 81442, Saudi Arabia.ORCID 0000-0002-5055-6256
Hana SonbolDepartment of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia.ORCID 0000-0001-7074-5444
Nabeel AhmadDepartment of Biotechnology, School of Allied Sciences, Dev Bhoomi Uttarakhand University, Dehradun 248007, India.
Syed Shah Mohammed FaiyazDepartment of Physiology, College of Medicine, University of Ha'il, Ha'il 81442, Saudi Arabia.ORCID 0000-0002-7558-0834
Mohammad Amjad KamalInstitutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610065, China.
El-Sayed KhafagyDepartment of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.ORCID 0000-0002-3741-0893
Afrasim MoinDepartment of Pharmaceutics, College of Pharmacy, University of Ha'il, Ha'il 81442, Saudi Arabia.ORCID 0000-0002-3902-1162
Amr Selim Abu LilaDepartment of Pharmaceutics, College of Pharmacy, University of Ha'il, Ha'il 81442, Saudi Arabia.ORCID 0000-0001-7385-868X

Funding

University of Hail MDR-22 008
6 · The paper itself

Abstract

Infections caused by resistant bacterial pathogens have increased the complications of clinicians worldwide. The quest for effective antibacterial agents against resistant pathogens has prompted researchers to develop new classes of antibiotics. Unfortunately, pathogens have acted more smartly by developing resistance to even the newest class of antibiotics with time. The culture sensitivity analysis of the clinical samples revealed that pathogens are gaining resistance toward the new generations of cephalosporins at a very fast rate globally. The current study developed gold nanoparticles (AuNPs) that could efficiently deliver the 2nd (cefotetan-CT) and 3rd (cefixime-CX) generation cephalosporins to resistant clinical pathogens. In fact, both CT and CX were used to reduce and stabilize AuNPs by applying a one-pot synthesis approach, and their characterization was performed via spectrophotometry, dynamic light scattering and electron microscopy. Moreover, the synthesized AuNPs were tested against uro-pathogenic resistant clinical strains of

Indexed as

antibiotic resistancecefiximecefotetanclinical pathogensgold nanoparticles

Identifiers

PMID36770436
PMCPMC9919271

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.