Evidence map›Paper›PMID 36769988›Full record

ArticleMaterials (Basel, Switzerland)2023

Novel Nanocomposite Hydrogels Based on Crosslinked Microbial Polysaccharide as Potential Bioactive Wound Dressings.

Maria Minodora Marin, Madalina Albu Kaya, Durmus Alpaslan Kaya, Roxana Constantinescu, Bogdan Trica, Ioana Catalina Gifu, Elvira Alexandrescu, Cristina Lavinia Nistor, Rebeca Leu Alexa, Raluca Ianchis

Abstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maria Minodora MarinNational Research and Development Institute for Textile and Leather, Division Leather and Footwear Research Institute, Department of Collagen, 93 Ion Minulescu Str., 031215 Bucharest, Romania.
Madalina Albu KayaNational Research and Development Institute for Textile and Leather, Division Leather and Footwear Research Institute, Department of Collagen, 93 Ion Minulescu Str., 031215 Bucharest, Romania.ORCID 0000-0001-9960-2244
Durmus Alpaslan KayaNational Research and Development Institute for Textile and Leather, Division Leather and Footwear Research Institute, Department of Collagen, 93 Ion Minulescu Str., 031215 Bucharest, Romania.
Roxana ConstantinescuNational Research and Development Institute for Textile and Leather, Division Leather and Footwear Research Institute, Department of Collagen, 93 Ion Minulescu Str., 031215 Bucharest, Romania.
Bogdan TricaNational Research and Development Institute for Chemistry and Petrochemistry ICECHIM, Spl. Independentei 202, 6th District, 0600021 Bucharest, Romania.ORCID 0000-0002-9948-6914
Ioana Catalina GifuNational Research and Development Institute for Chemistry and Petrochemistry ICECHIM, Spl. Independentei 202, 6th District, 0600021 Bucharest, Romania.ORCID 0000-0002-2854-1998
Elvira AlexandrescuNational Research and Development Institute for Chemistry and Petrochemistry ICECHIM, Spl. Independentei 202, 6th District, 0600021 Bucharest, Romania.ORCID 0000-0002-5378-692X
Cristina Lavinia NistorNational Research and Development Institute for Chemistry and Petrochemistry ICECHIM, Spl. Independentei 202, 6th District, 0600021 Bucharest, Romania.ORCID 0000-0002-9200-5807
Rebeca Leu AlexaAdvanced Polymer Materials Group, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 1-7 Polizu Street, 01106 Bucharest, Romania.
Raluca IanchisNational Research and Development Institute for Chemistry and Petrochemistry ICECHIM, Spl. Independentei 202, 6th District, 0600021 Bucharest, Romania.ORCID 0000-0002-5540-2774

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A multitude of dressings have been developed to promote wound repair, such as membranes, foams, hydrocolloids and hydrogels. In this study, a crosslinked polysaccharide hydrogel was mixed with a bioactive ingredient to synthesize a novel nanocomposite material to be used in wound healing. Variation of the ratio between hydrogel components was followed and its effect was analyzed in regard to swelling, degradation rate and thermo-mechanical behavior. The resulting crosslinked structures were characterized by FTIR and microscopy analyses. The antimicrobial activity of the crosslinked hydrogels loaded with bioactive agent was evaluated using two bacterial strains (Gram-positive Staphylococcus aureus and Gram-negative bacteria Escherichia Coli). All the results showed that the new synthesized biopolymer nanocomposites have adequate properties to be used as antibacterial wound dressings.

Indexed as

antimicrobialhydrogelspolysaccharidesalecansilver nanoparticles

Identifiers

PMID36769988
PMCPMC9920030

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.