Evidence map›Paper›PMID 36769836›Full record

ReviewJournal of clinical medicine2023

Old and New Precipitants in Hepatic Encephalopathy: A New Look at a Field in Continuous Evolution.

Daniele Bellafante, Stefania Gioia, Jessica Faccioli, Oliviero Riggio, Lorenzo Ridola, Silvia Nardelli

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Management of Refractory Hepatic Encephalopathy.Digestive diseases and sciences · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Daniele BellafanteDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00185 Roma, Italy.
Stefania GioiaDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00185 Roma, Italy.
Jessica FaccioliDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00185 Roma, Italy.ORCID 0000-0001-6960-9701
Oliviero RiggioDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00185 Roma, Italy.
Lorenzo RidolaDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00185 Roma, Italy.ORCID 0000-0002-8596-2609
Silvia NardelliDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00185 Roma, Italy.ORCID 0000-0002-7038-9539

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatic encephalopathy (HE) is a common complication in patients with advanced liver disease. It is a brain dysfunction characterized by neurological and psychiatric symptoms that significantly affects quality of life, morbidity and mortality of patients. HE has various precipitants that can potentially promote its onset, alone or in combination. Among the historically well-known precipitants, such as infections, gastrointestinal bleeding, dehydration, electrolyte disorders and constipation, recent studies have highlighted the role of malnutrition and portosystemic shunts as new precipitating factors of HE. The identification, management and correction of these factors are fundamental for effective HE treatment, in addition to pharmacological therapy with non-absorbable disaccharides and/or antibiotics.

Indexed as

ammonialiver cirrhosisminimal hepatic encephalopathyovert hepatic encephalopathyportosystemic shuntssarcopenia

Identifiers

PMID36769836
PMCPMC9917479

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.