ReviewJournal of clinical medicine2023
Neuroimaging Studies of the Neural Correlates of Heart Rate Variability: A Systematic Review.
Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Manual Therapy in Indirect Non-Invasive Neuromodulation of the Vagus Nerve in the Treatment of Bruxism in Young Adult Population up to 40 Years Old
Efficacy of Manual Therapy in Indirect Non-Invasive Neuromodulation of the Vagus Nerve in the Treatment of Bruxism in Young Adult Population up to 40 Years Old
Multisensory Therapy Alleviating MRI-Related Anxiety in Cancer Patients Via Brain-Autonomic Network Modulation: A Randomized Clinical Trial
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Heart Rate Variability and Coronary Artery Bypass Grafting: A Systematic Review.Reviews in cardiovascular medicine · 2024Pooled it
- The Impact of Alpha-Neurofeedback Training on Gastric Slow Wave Activity and Heart Rate Variability in Humans.Neurogastroenterology and motility · 2025Trial
- Effects of cortisol administration on heart rate variability and functional connectivity across women with different depression histories.Behavioural brain research · 2024Trial
- The effect of cranial techniques on the heart rate variability response to psychological stress test in firefighter cadets.Scientific reports · 2023Trial
- Acute Psychophysiological Effects Of 4-7-8 And Nadi Shodhana Breathing: A Randomized Crossover Study.Applied psychophysiology and biofeedback · 2026Article
- From Molecules to Meaning: Integrating Neuropeptides, Sociostasis, and Hormesis in the Brain-Heart Axis.Current issues in molecular biology · 2026Review
- Baseline vagal tone and pain reactivity: linking autonomic function to endogenous pain inhibition in women.Pain reports · 2026Article
- Left ventricular parameters and mass indexing methods in cardiac magnetic resonance imaging in prediction of major adverse cardiovascular events and mortality.Quantitative imaging in medicine and surgery · 2026Article
- Daily Paced Breathing Sessions Induce Left Orbitofrontal Volume Changes Linked to Cognitive Outcomes.medRxiv : the preprint server for health sciences · 2026Article
- Article
- Limited evidence for heart rate variability as a predictor of cognitive and pathophysiological brain markers.Journal of Alzheimer's disease : JAD · 2026Article
- Through Massage to the Brain-Neuronal and Neuroplastic Mechanisms of Massage Based on Various Neuroimaging Techniques (EEG, fMRI, and fNIRS).Journal of clinical medicine · 2026Review
- Research hotspots and trend of the heart-brain axis by MRI: a bibliometric analysis.Frontiers in cardiovascular medicine · 2026Article
- Neurophysiological mechanisms of breathing-based well-being practices: a narrative review for clinical application.Frontiers in psychiatry · 2026Review
- MRI methods for the study of central nervous system involvement in autonomic function.Frontiers in network physiology · 2026Review
- Central autonomic network dysfunction in Stroke-Heart Syndrome: mechanistic roles of the insula and limbic system.Frontiers in neuroscience · 2026Review
- The involvement of attentional biases in endogenous pain inhibition and autonomic reactivity.PloS one · 2026Article
- Heart rate variability in epilepsy and its association with disease duration: a retrospective case-control study.Frontiers in neurology · 2026Article
- An Exploratory Pilot Study of Brain Functional Connectivity and Heart Rate Variability in Male Children With Autism Spectrum Disorder.Journal of the Korean Academy of Child and Adolescent Psychiatry · 2026Article
- The relationship of early life adversity and physiological synchrony within the therapeutic triad in horse-assisted therapy.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Direct and indirect links between brain regions and cardiac function have been reported. We performed a systematic literature review to summarize current knowledge regarding the associations of heart rate variability (HRV) and brain region morphology, activity and connectivity involved in autonomic control at rest in healthy subjects. Both positive and negative correlations of cortical thickness and gray matter volumes of brain structures with HRV were observed. The strongest were found for a cluster located within the cingulate cortex. A decline in HRV, as well as cortical thickness with increasing age, especially in the orbitofrontal cortex were noted. When associations of region-specific brain activity with HRV were examined, HRV correlated most strongly with activity in the insula, cingulate cortex, frontal and prefrontal cortices, hippocampus, thalamus, striatum and amygdala. Furthermore, significant correlations, largely positive, between HRV and brain region connectivity (in the amygdala, cingulate cortex and prefrontal cortex) were observed. Notably, right-sided neural structures may be preferentially involved in heart rate and HRV control. However, the evidence for left hemispheric control of cardiac vagal function has also been reported. Our findings provide support for the premise that the brain and the heart are interconnected by both structural and functional networks and indicate complex multi-level interactions. Further studies of brain-heart associations promise to yield insights into their relationship to health and disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.