Evidence map›Paper›PMID 36769646›Full record

ArticleJournal of clinical medicine2023

The Therapeutic Intensity Score as Predictor of Clinical Outcomes after Total and Partial Adrenalectomy for Unilateral Primary Aldosteronism: Results of a Multicentric Series.

Umberto Anceschi, Marilda Mormando, Rocco Simone Flammia, Cristian Fiori, Orazio Zappalà, Bernardino De Concilio, Aldo Brassetti, Alessandro Carrara, Maria Consiglia Ferriero, Gabriele Tuderti and 10 more

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Umberto AnceschiIRCCS "Regina Elena" National Cancer Institute, Department of Urology, Via Elio Chianesi, 00144 Rome, Italy.ORCID 0000-0002-7586-4132
Marilda MormandoIRCCS "Regina Elena" National Cancer Institute, Oncologic Endocrinology Unit, Via Elio Chianesi, 00144 Rome, Italy.
Rocco Simone Flammia"La Sapienza" University of Rome, Department of Maternal Infant and Urologic Sciences, Policlinico Umberto I, Viale del Policlinico, 00161 Rome, Italy.ORCID 0000-0002-3129-0544
Cristian FioriAOU San Luigi Gonzaga, Department of Urology, Regione Gonzole, 10043 Orbassano, Italy.
Orazio ZappalàAPSS, Santa Chiara Regional Hospital, Department of General Surgery, Largo Medaglie d'Oro, 38122 Trento, Italy.
Bernardino De ConcilioULSS 7 Pedemontana, San Bassiano Hospital, Department of Urology, Via dei Lotti, 36061 Bassano del Grappa, Italy.
Aldo BrassettiIRCCS "Regina Elena" National Cancer Institute, Department of Urology, Via Elio Chianesi, 00144 Rome, Italy.ORCID 0000-0001-9643-8979
Alessandro CarraraAPSS, Santa Maria del Carmine Hospital, Department of General Surgery, Corso Verona, 38068 Rovereto, Italy.
Maria Consiglia FerrieroIRCCS "Regina Elena" National Cancer Institute, Department of Urology, Via Elio Chianesi, 00144 Rome, Italy.
Gabriele TudertiIRCCS "Regina Elena" National Cancer Institute, Department of Urology, Via Elio Chianesi, 00144 Rome, Italy.ORCID 0000-0003-4480-9090
Leonardo MisuracaIRCCS "Regina Elena" National Cancer Institute, Department of Urology, Via Elio Chianesi, 00144 Rome, Italy.
Francesco PrataIRCCS "Regina Elena" National Cancer Institute, Department of Urology, Via Elio Chianesi, 00144 Rome, Italy.ORCID 0000-0003-3084-6210
Antonio Tufano"La Sapienza" University of Rome, Department of Maternal Infant and Urologic Sciences, Policlinico Umberto I, Viale del Policlinico, 00161 Rome, Italy.
Alfredo Maria BoveIRCCS "Regina Elena" National Cancer Institute, Department of Urology, Via Elio Chianesi, 00144 Rome, Italy.
Riccardo MastroianniIRCCS "Regina Elena" National Cancer Institute, Department of Urology, Via Elio Chianesi, 00144 Rome, Italy.ORCID 0000-0003-3708-2209
Marialuisa AppetecchiaIRCCS "Regina Elena" National Cancer Institute, Oncologic Endocrinology Unit, Via Elio Chianesi, 00144 Rome, Italy.ORCID 0000-0002-2124-1335
Giuseppe TironeAPSS, Santa Chiara Regional Hospital, Department of General Surgery, Largo Medaglie d'Oro, 38122 Trento, Italy.
Francesco PorpigliaAOU San Luigi Gonzaga, Department of Urology, Regione Gonzole, 10043 Orbassano, Italy.
Antonio CeliaULSS 7 Pedemontana, San Bassiano Hospital, Department of Urology, Via dei Lotti, 36061 Bassano del Grappa, Italy.
Giuseppe SimoneIRCCS "Regina Elena" National Cancer Institute, Department of Urology, Via Elio Chianesi, 00144 Rome, Italy.ORCID 0000-0002-4868-9025

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate the ability of therapeutic intensity score (TIS) in predicting the clinical outcomes of partial (PA) and total adrenalectomy (TA) for UPA.

methodsBetween 2011 and 2022, a four-center adrenalectomy dataset was queried for "unilateral adrenal mass" and "UPA" (n = 90). Preoperative TIS of each antihypertensive medication were individually calculated and merged to create a single, cumulative variable. Probability of complete clinical, partial, and absent pooled success rates according to TIS were assessed for the overall cohort by Kaplan-Meier. Cox analyses were used to identify predictors of complete clinical and partial/absent success, respectively. For all analyses, a two-sided

resultsAt a median follow-up of 42 months (IQR 27-54) complete partial, and absent clinical success were observed in 60%, 17.7%, and 22.3%, respectively. On Kaplan-Meier analysis, TIS < 1 predicted higher complete success rates (

conclusionsTIS score and adenoma size may help to identify patients who are likely to be at risk of persistent hypertension after surgery.

Indexed as

Conn’s syndromehypertensionoutcomespartial adrenalectomyPASOprimary aldosteronism

Identifiers

PMID36769646
PMCPMC9917842

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.