Evidence map›Paper›PMID 36769446›Full record

ArticleJournal of clinical medicine2023

Wnt7b: Is It an Important Factor in the Bone Formation Process after Calvarial Damage?

Bo Feng, Jun Pei, Shensheng Gu

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Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Bo FengDepartment of Endodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Jun PeiCollege of Stomatology, Shanghai Jiao Tong University, Shanghai 200125, China.
Shensheng GuDepartment of Endodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.

Funding

Fundamental Research Program Founding of Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine JYZZ141Natural Science Foundation of Shanghai No. 20ZR1448700
6 · The paper itself

Abstract

objectivePrevious studies found that Wnt7b played a unique and indispensable role in the process of osteoblast differentiation and could accelerate the repair of bone loss. However, what is the role of Wnt7B in osteogenesis? Is it possible to increase the expression of Wnt7b to promote the repair of skull defects? This study intends to provide the basic data for the application of Wnt7b in the treatment of craniomaxillofacial bone repair.

methodsA calvarial defect mouse model that could induce Wnt7b overexpression was established. Three days after the operation, the mice in each group were intraperitoneally injected with tamoxifen (TAM) or oil eight times every other day. There were three groups. The TAMc group (R26

resultsFour weeks after the operation, bone healing conditions were measured by using micro-CT scanning. The defect area of the TAM group was smaller than that of the other groups. Similarly, the bone volume fraction (BV/TV) significantly increased (

conclusionsWnt7b participates in the bone formation process after calvarial damage, indicating the important role of Wnt7b in osteogenesis.

Indexed as

bone formationcalvarial damagecalvarial defect modelosteogenesisWnt7b

Identifiers

PMID36769446
PMCPMC9917507

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