Evidence map›Paper›PMID 36769421›Full record

ArticleJournal of clinical medicine2023

Prognostic Role of Sonographic Decongestion in Patients with Acute Heart Failure with Reduced and Preserved Ejection Fraction: A Multicentre Study.

Nicola R Pugliese, Matteo Mazzola, Giulia Bandini, Greta Barbieri, Stefano Spinelli, Nicolò De Biase, Stefano Masi, Alberto Moggi-Pignone, Lorenzo Ghiadoni, Stefano Taddei and 4 more

Abstract read
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Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Observational
  9. Article
  10. Systematic implementation of cardiopulmonary ultrasound imaging to optimize management of acute decompensated heart failure.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2024
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nicola R PuglieseDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-5473-227X
Matteo MazzolaDepartment of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, 56126 Pisa, Italy.
Giulia BandiniDepartment of Experimental and Clinical Medicine, Azienda Ospedaliera Universitaria Careggi, 50134 Florence, Italy.
Greta BarbieriDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Stefano SpinelliDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-2833-6484
Nicolò De BiaseDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Stefano MasiDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-7591-3686
Alberto Moggi-PignoneDepartment of Experimental and Clinical Medicine, Azienda Ospedaliera Universitaria Careggi, 50134 Florence, Italy.
Lorenzo GhiadoniDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Stefano TaddeiDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Rosa SicariInstitute of Clinical Physiology-National Research Council, 56124 Pisa, Italy.
Peter S PangDepartment of Emergency Medicine, Indiana University, Indianapolis, IN 46617, USA.
Marco De CarloCardiothoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana, 56124 Pisa, Italy.ORCID 0000-0002-5763-9804
Luna GarganiDepartment of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-0716-453X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe investigated the role of the dynamic changes of pulmonary congestion, as assessed by sonographic B-lines, as a tool to stratify prognosis in patients admitted for acute heart failure with reduced and preserved ejection fraction (HFrEF, HFpEF).

methodsIn this multicenter, prospective study, lung ultrasound was performed at admission and before discharge by trained investigators, blinded to clinical findings.

resultsWe enrolled 208 consecutive patients (mean age 76 [95% confidence interval, 70-84] years), 125 with HFrEF, 83 with HFpEF (mean ejection fraction 32% and 57%, respectively). The primary composite endpoint of cardiovascular death or HF re-hospitalization occurred in 18% of patients within 6 months. In the overall population, independent predictors of the occurrence of the primary endpoint were the number of B-lines at discharge, NT-proBNP levels, moderate-to-severe mitral regurgitation, and inferior vena cava diameter on admission. B-lines at discharge were the only independent predictor in both HFrEF and HFpEF subgroups. A cut-off of B-lines > 15 at discharge displayed the highest accuracy in predicting the primary endpoint (AUC = 0.80,

conclusionsThe presence of residual subclinical sonographic pulmonary congestion at discharge predicts 6-month clinical outcomes across the whole spectrum of acute HF patients, independent of conventional biohumoral and echocardiographic parameters. Achieving effective pulmonary decongestion during hospitalization is associated with better outcomes.

Indexed as

acute heart failureB-lineslung ultrasoundpulmonary congestion

Identifiers

PMID36769421
PMCPMC9917462

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