Evidence map›Paper›PMID 36769350›Full record

ArticleInternational journal of molecular sciences2023

A Functional Polymorphism Downstream of Vitamin A Regulator Gene

Vivia Khosasih, Kai-Ming Liu, Chung-Ming Huang, Lieh-Bang Liou, Ming-Shium Hsieh, Chian-Her Lee, Chang-Youh Tsai, San-Yuan Kuo, Su-Yang Hwa, Chia-Li Yu and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Vivia KhosasihTaiwan International Graduate Program in Molecular Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taipei 115, Taiwan.ORCID 0000-0002-6451-3556
Kai-Ming LiuNational Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.
Chung-Ming HuangDivision of Immunology and Rheumatology, Department of Internal Medicine, China Medical University Hospital, Taichung 404, Taiwan.
Lieh-Bang LiouDivision of Rheumatology, Allergy and Immunology, New Taipei Municipal Tucheng Hospital, New Taipei City 236, Taiwan.
Ming-Shium HsiehDepartment of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Chian-Her LeeDepartment of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Chang-Youh TsaiSchool of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.ORCID 0000-0002-4154-4018
San-Yuan KuoDivision of Rheumatology, Immunology and Allergy, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.
Su-Yang HwaDepartment of Orthopaedics, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.
Chia-Li YuDepartment of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan.ORCID 0000-0003-4988-0400
Chih-Hao ChangDepartment of Orthopedics, College of Medicine, National Taiwan University and National Taiwan University Hospital, Taipei 100, Taiwan.ORCID 0000-0001-9794-0610
Cheng-Jyh LinDepartment of Orthopedics, China Medical University Hospital, Taichung 404, Taiwan.
Song-Chou HsiehDivision of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan.
Chun-Ying ChengCollege of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Wei-Ming ChenSchool of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.
Liang-Kuang ChenDepartment of Diagnostic Radiology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111, Taiwan.
Hui-Ping ChuangNational Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.
Ying-Ting ChenNational Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.
Pei-Chun TsaiNational Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.
Liang-Suei LuNational Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.
Weng-Siong H'ngNational Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.ORCID 0000-0002-0571-258X
Yanfei ZhangGenomic Medicine Institute, Geisinger, Danville, PA 17822, USA.ORCID 0000-0002-9222-7725
Hsiang-Cheng ChenDivision of Rheumatology, Immunology and Allergy, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.ORCID 0000-0002-0753-6161
Chien-Hsiun ChenNational Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.ORCID 0000-0003-2140-033X
Ming Ta Michael LeeGenomic Medicine Institute, Geisinger, Danville, PA 17822, USA.
Jer-Yuarn WuTaiwan International Graduate Program in Molecular Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taipei 115, Taiwan.

Funding

Academia Sinica AS-GMM-110-01
6 · The paper itself

Abstract

While genetic analyses have revealed ~100 risk loci associated with osteoarthritis (OA), only eight have been linked to hand OA. Besides, these studies were performed in predominantly European and Caucasian ancestries. Here, we conducted a genome-wide association study in the Han Chinese population to identify genetic variations associated with the disease. We recruited a total of 1136 individuals (n = 420 hand OA-affected; n = 716 unaffected control subjects) of Han Chinese ancestry. We carried out genotyping using Axiom Asia Precisi on Medicine Research Array, and we employed the RegulomeDB database and RoadMap DNase I Hypersensitivity Sites annotations to further narrow down our potential candidate variants. Genetic variants identified were tested in the Geisinger's hand OA cohort selected from the Geisinger MyCode community health initiative (MyCode

Indexed as

OsteoarthritisVitamin AAllelesCase-Control StudiesChinaGenes, RegulatorGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansPolymorphism, Single NucleotideRetinoic Acid 4-HydroxylaseCYP26B1 protein, humanRetinoic Acid 4-HydroxylaseVitamin ACYP26B1genome-wide association studyHan Chinesehand osteoarthritispolymorphismsretinoic acid

Identifiers

PMID36769350
PMCPMC9918232

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.