ReviewInternational journal of molecular sciences2023
RANKL-RANK-OPG Pathway in Charcot Diabetic Foot: Pathophysiology and Clinical-Therapeutic Implications.
Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pharmacological treatment for Charcot neuroarthropathy: a systematic review.BMC musculoskeletal disorders · 2026Pooled it
- The diabetic neuropathy and bone mineral density in type 2 diabetes mellitus: a cross-sectional and meta-analytic study.Clinical and experimental medicine · 2025Pooled it
- Ultrasonography Cannot Exclude Osteomyelitis in Diabetic Foot Ulcers: A Cross-Sectional Diagnostic Accuracy Study Against Magnetic Resonance Imaging.Endocrinology, diabetes & metabolism · 2026Article
- Bone‑origin repair in diabetic foot ulcers: Mechanisms of callus formation and endocrine effects in healing (Review).International journal of molecular medicine · 2026Review
- Quantitative assessment of active charcot neuro-osteoarthropathy in diabetes usingFrontiers in endocrinology · 2026Article
- Diabetic Charcot Neuroarthropathy: A Contemporary Review of Molecular and Genetic Markers.Foot & ankle international · 2026Review
- [Diabetic Charcot neuroarthropathy initially misdiagnosed as rheumatoid arthritis and gout: A case report].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2025Article
- Association of Inflammatory and Cardiovascular Proteomics Biomarkers With Indices of Heart Rate Variability in the General Population: KORA S4/FF4 Study.Journal of the American Heart Association · 2025Article
- Charcot foot disease: A new approach.Drugs & aging · 2025Review
- Management of hindfoot and ankle in Charcot arthropathy.EFORT open reviews · 2025Article
- A comprehensive review and advanced biomolecule-based therapies for osteoporosis.Journal of advanced research · 2025Review
- Treatment Options of Prosthetic Joint Infections Following Total Ankle Arthroplasty: A Systematic Review.Journal of clinical medicine · 2025Review
- Demographic and Clinical Characteristics of Patients With Charcot Neuro-Osteoarthropathy in People With Diabetes Mellitus in Six Countries: A Multicenter Observational Study From 1996 to 2022.Journal of diabetes research · 2025Observational
- Long-Term Outcomes of a Novel Surgical Approach for Early Charcot Neuroarthropathy.Case reports in orthopedics · 2025Article
- Inflammation, diabetic foot and related treatments.Frontiers in endocrinology · 2025Review
- Predictive Factors of Amputation in Diabetic Foot.Biomedicines · 2024Article
- The Pathogenetic Role of RANK/RANKL/OPG Signaling in Osteoarthritis and Related Targeted Therapies.Biomedicines · 2024Review
- Charcot arthropathy of the knee accompanied by tethered cord syndrome and lumbosacral fur sinus.Heliyon · 2024Article
- Effectiveness of Pamidronate Infusion in the Treatment of Charcot Arthropathy.Malaysian orthopaedic journal · 2024Article
- [Progress in clinical diagnosis and treatment of diabetic Charcot neuroarthropathy of foot and ankle].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Charcot Foot (CF), part of a broader condition known as Charcot Neuro-Osteoarthropathy (CNO), is characterized by neuropathic arthropathy with a progressive alteration of the foot. CNO is one of the most devastating complications in patients with diabetes mellitus and peripheral neuropathy but can also be caused by neurological or infectious diseases. The pathogenesis is multifactorial; many studies have demonstrated the central role of inflammation and the Receptor Activator of NF-κB ligand (RANKL)-Receptor Activator of NF-κB (RANK)-Osteoprotegerin (OPG) pathway in the acute phase of the disease, resulting in the serum overexpression of RANKL. This overexpression and activation of this signal lead to increased osteoclast activity and osteolysis, which is a prelude to bone destruction. The aim of this narrative review is to analyze this signaling pathway in bone remodeling, and in CF in particular, to highlight its clinical aspects and possible therapeutic implications of targeting drugs at different levels of the pathway. Drugs that act at different levels in this pathway are anti-RANKL monoclonal antibodies (Denosumab), bisphosphonates (BP), and calcitonin. The literature review showed encouraging data on treatment with Denosumab, although in a few studies and in small sample sizes. In contrast, BPs have been re-evaluated in recent years in relation to the high possibility of side effects, while calcitonin has shown little efficacy on CNO.
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