Evidence map›Paper›PMID 36769327›Full record

ArticleInternational journal of molecular sciences2023

BTEAC Catalyzed Ultrasonic-Assisted Synthesis of Bromobenzofuran-Oxadiazoles: Unravelling Anti-HepG-2 Cancer Therapeutic Potential through In Vitro and In Silico Studies.

Ali Irfan, Ameer Fawad Zahoor, Azhar Rasul, Sami A Al-Hussain, Shah Faisal, Sajjad Ahmad, Rida Noor, Muhammed Tilahun Muhammed, Magdi E A Zaki

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Ali IrfanDepartment of Chemistry, Government College University Faisalabad, Faisalabad 38000, Pakistan.ORCID 0000-0002-8977-3303
Ameer Fawad ZahoorDepartment of Chemistry, Government College University Faisalabad, Faisalabad 38000, Pakistan.ORCID 0000-0003-2127-8848
Azhar RasulDepartment of Zoology, Government College University Faisalabad, Faisalabad 38000, Pakistan.ORCID 0000-0001-9669-7364
Sami A Al-HussainDepartment of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia.
Shah FaisalDepartment of Chemistry, Islamia College University Peshawar, Peshawar 25120, Pakistan.ORCID 0000-0002-5105-6982
Sajjad AhmadDepartment of Health and Biological Sciences, Abasyn University, Peshawar 25000, Pakistan.ORCID 0000-0003-0754-1742
Rida NoorDepartment of Chemistry, Government College University Faisalabad, Faisalabad 38000, Pakistan.
Muhammed Tilahun MuhammedDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Suleyman Demirel University, Isparta 32260, Turkey.ORCID 0000-0003-0050-5271
Magdi E A ZakiDepartment of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia.ORCID 0000-0002-5643-9202
Government College University, Faisalabad · PKImam Mohammad ibn Saud Islamic University · SAAbasyn University · PKIslamia College University · PKSüleyman Demirel University · TR

Funding

The authors thank the Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University for funding this work through Research Group no. RG 21-09-76 Research Group no. RG 21-09-76
6 · The paper itself

Abstract

In this work, BTEAC (benzyl triethylammonium chloride) was employed as a phase transfer catalyst in an improved synthesis (up to 88% yield) of S-alkylated bromobenzofuran-oxadiazole scaffolds

Indexed as

Antineoplastic AgentsNeoplasmsCatalysisCell Line, TumorCell ProliferationErbB ReceptorsGlycogen Synthase Kinase 3 betaHumansMolecular Docking SimulationMolecular StructureOxadiazolesPhosphatidylinositol 3-KinasesStructure-Activity RelationshipTOR Serine-Threonine KinasesTubulinUltrasonicsAntineoplastic AgentsErbB ReceptorsGlycogen Synthase Kinase 3 betaOxadiazolesPhosphatidylinositol 3-KinasesTOR Serine-Threonine KinasesTubulinbromobenzofuran-oxadiazoleBTEACDFT studiesEGFRHepG-2 cell lineMD simulationsmolecular dockingPI3K, mTOR and tubulin polymerization inhibitorsSAR

Identifiers

PMID36769327
PMCPMC9917671
OpenAlexW4319081624

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.