Evidence map›Paper›PMID 36769319›Full record

ArticleInternational journal of molecular sciences2023

The In Vitro Impact of Isoxazole Derivatives on Pathogenic Biofilm and Cytotoxicity of Fibroblast Cell Line.

Urszula Bąchor, Adam Junka, Malwina Brożyna, Marcin Mączyński

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Investigating the cytotoxic effect of polyethyleneimine nanodendrimer on fibroblast cells.International journal of physiology, pathophysiology and pharmacology · 2026
    Article
  3. Review
  4. Article
  5. Novel Isoxazole-Based Antifungal Drug Candidates.International journal of molecular sciences · 2024
    Article
  6. Article
  7. Review
  8. SMR peptide antagonizesMicrobiology spectrum · 2024
    Article
  9. Article
  10. Review
  11. Recent Approaches for Wound Treatment.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Urszula BąchorDepartment of Organic Chemistry and Drug Technology, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, Poland.
Adam JunkaUnique Application Model Laboratory, Department of Pharmaceutical Microbiology and Parasitology, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, Poland.ORCID 0000-0002-7559-8903
Malwina BrożynaUnique Application Model Laboratory, Department of Pharmaceutical Microbiology and Parasitology, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, Poland.ORCID 0000-0001-9520-3377
Marcin MączyńskiDepartment of Organic Chemistry and Drug Technology, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, Poland.ORCID 0000-0001-6110-344X

Funding

Wroclaw Medical University SUB.D090.22.053
6 · The paper itself

Abstract

The microbial, biofilm-based infections of chronic wounds are one of the major challenges of contemporary medicine. The use of topically administered antiseptic agents is essential to treat wound-infecting microorganisms. Due to observed microbial tolerance/resistance against specific clinically-used antiseptics, the search for new, efficient agents is of pivotal meaning. Therefore, in this work, 15 isoxazole derivatives were scrutinized against leading biofilm wound pathogens

Indexed as

Anti-Infective Agents, LocalIsoxazolesAnimalsAnti-Bacterial AgentsBiofilmsCell LineFibroblastsMicrobial Sensitivity TestsOxazolesPseudomonas aeruginosaStaphylococcus aureusAnti-Bacterial AgentsAnti-Infective Agents, LocalIsoxazolesOxazolesanti-bacterial activityantisepticscytotoxicityisoxazoleMichael additionPasserini reaction

Identifiers

PMID36769319
PMCPMC9917413

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.