Evidence map›Paper›PMID 36769302›Full record

ArticleInternational journal of molecular sciences2023

Asparagine and Glutamine Deprivation Alters Ionizing Radiation Response, Migration and Adhesion of a p53

Isabella Guardamagna, Ombretta Iaria, Leonardo Lonati, Alice Mentana, Andrea Previtali, Virginia Uggè, Giovanni Battista Ivaldi, Marco Liotta, Paola Tabarelli de Fatis, Claudia Scotti and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Metabolism of asparagine in the physiological state and cancer.Cell communication and signaling : CCS · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Isabella GuardamagnaLaboratory of Radiation Biophysics and Radiobiology, Department of Physics, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0002-2669-451X
Ombretta IariaLaboratory of Radiation Biophysics and Radiobiology, Department of Physics, University of Pavia, 27100 Pavia, Italy.
Leonardo LonatiLaboratory of Radiation Biophysics and Radiobiology, Department of Physics, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0002-5733-260X
Alice MentanaLaboratory of Radiation Biophysics and Radiobiology, Department of Physics, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0001-5370-0308
Andrea PrevitaliLaboratory of Radiation Biophysics and Radiobiology, Department of Physics, University of Pavia, 27100 Pavia, Italy.
Virginia UggèLaboratory of Radiation Biophysics and Radiobiology, Department of Physics, University of Pavia, 27100 Pavia, Italy.
Giovanni Battista IvaldiUnit of Radiation Oncology, ICS Maugeri, IRCCS, 27100 Pavia, Italy.ORCID 0000-0002-7280-5698
Marco LiottaUnit of Medical Physics, ICS Maugeri, IRCCS, 27100 Pavia, Italy.
Paola Tabarelli de FatisUnit of Medical Physics, ICS Maugeri, IRCCS, 27100 Pavia, Italy.
Claudia ScottiUnit of Immunology and General Pathology, Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0002-5790-1833
Greta PessinoUnit of Immunology and General Pathology, Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0001-6504-9882
Maristella MaggiUnit of Immunology and General Pathology, Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0002-9075-8143
Giorgio BaioccoLaboratory of Radiation Biophysics and Radiobiology, Department of Physics, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0003-2866-6392

Funding

ASSOCIAZIONE GIAN FRANCO LUPO - UN SORRISO ALLA VITA ONLUS NAMinistry of Education, Universities and Research NA
6 · The paper itself

Abstract

Colorectal cancer (CRC) is the most prominent form of colon cancer for both incidence (38.7 per 100,000 people) and mortality (13.9 per 100,000 people). CRC's poor response to standard therapies is linked to its high heterogeneity and complex genetic background. Dysregulation or depletion of the tumor suppressor p53 is involved in CRC transformation and its capability to escape therapy, with p53

Indexed as

Colonic NeoplasmsColorectal NeoplasmsAsparaginaseAsparagineCaco-2 CellsCell Line, TumorGlutamineHumansRadiation, IonizingTumor Suppressor Protein p53AsparaginaseAsparagineGlutamineTumor Suppressor Protein p53adhesionautophagycolorectal cancerextracellular matrixɣH2AXL-Asparaginasep53radiotherapy

Identifiers

PMID36769302
PMCPMC9917910

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.