Evidence map›Paper›PMID 36769169›Full record

ArticleInternational journal of molecular sciences2023

Functional Characterization of a Familial ALS-Associated Missense

Gracia Porras, Silvana Ruiz, Inés Maestro, Daniel Borrego-Hernández, Alberto G Redondo, Ana Martínez, Ángeles Martín-Requero

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Amyotrophic Lateral Sclerosis as a Systemic Disease.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gracia PorrasDepartment of Molecular Biomedicine, Centro de Investigaciones Biológicas, Margarita Salas (CSIC), Ramiro de Maeztu 9, 28040 Madrid, Spain.
Silvana RuizDepartment of Molecular Biomedicine, Centro de Investigaciones Biológicas, Margarita Salas (CSIC), Ramiro de Maeztu 9, 28040 Madrid, Spain.
Inés MaestroDepartment of Structural and Chemical Biology, Centro de Investigaciones Biológicas, Margarita Salas (CSIC), Ramiro de Maeztu 9, 28040 Madrid, Spain.
Daniel Borrego-HernándezALS Research Lab, Hospital 12 de Octubre Research Institute (i+12), 28041 Madrid, Spain.
Alberto G RedondoALS Research Lab, Hospital 12 de Octubre Research Institute (i+12), 28041 Madrid, Spain.ORCID 0000-0001-7646-386X
Ana MartínezDepartment of Structural and Chemical Biology, Centro de Investigaciones Biológicas, Margarita Salas (CSIC), Ramiro de Maeztu 9, 28040 Madrid, Spain.ORCID 0000-0002-2707-8110
Ángeles Martín-RequeroDepartment of Molecular Biomedicine, Centro de Investigaciones Biológicas, Margarita Salas (CSIC), Ramiro de Maeztu 9, 28040 Madrid, Spain.ORCID 0000-0002-3416-9440

Funding

Agencia Estal de Investigación RTI2018-096100-B-I00 and PID2019-105600RB-I00Biomedical Research Networking Center on Neurodegenerative Diseases CB18/05/00040Comunidad de Madrid B2017/BMD-3813Fundacion la Caixa-Luzón HR21-00931
6 · The paper itself

Abstract

The goal of this work was to elucidate the pathogenic mechanism of an ALS-associated missense mutation, p.Arg573Gly (R573G), in the

Indexed as

Amyotrophic Lateral SclerosisDNA-Binding ProteinsHumansMutationMutation, MissensePhosphorylationProtein Serine-Threonine KinasesDNA-Binding ProteinsProtein Serine-Threonine KinasesTBK1 protein, humanamyotrophic lateral sclerosislymphoblastsRIPK1TBK1TDP-43

Identifiers

PMID36769169
PMCPMC9917786

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.