ReviewInternational journal of molecular sciences2023
Plant Coumarins with Anti-HIV Activity: Isolation and Mechanisms of Action.
Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Artificial intelligence-driven discovery of coumarin-based therapeutics: Revolutionizing target identification and validation.Pharmaceutical science advances · 2026Review
- Coumarin derivatives as HIV-1 inhibitors: mechanistic insights and structure-activity relationships.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026Review
- Polyphenols from Byproducts: Their Applications and Health Effects.Antioxidants (Basel, Switzerland) · 2026Review
- The Role of Coumarins in Drug Discovery: Pharmacological Insights and Structural Innovations.Current topics in medicinal chemistry · 2026Review
- Medicinal plants of Sabah (North Borneo): lest we forget.Pharmaceutical biology · 2025Review
- Dual-Ligand Strategy in Rh-Catalyzed Sequential Hydrofunctionalization of Valylene.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Pharmacochemical Studies of Synthesized Coumarin-Isoxazole-Pyridine Hybrids.Molecules (Basel, Switzerland) · 2025Article
- Elucidating the Mechanism of Coumarin Homodimerization Using 3-Acetylcoumarin Derivatives.Molecules (Basel, Switzerland) · 2025Article
- Discovery ofFrontiers in chemistry · 2025Article
- An Overview on the Synthesis of Lamellarins and Related Compounds with Biological Interest.Molecules (Basel, Switzerland) · 2024Review
- Anti-HIV Activity and Immunomodulatory Properties of Fractionated Crude Extracts ofMicroorganisms · 2024Article
- Coumarin-furo[2,3-RSC medicinal chemistry · 2024Article
- Role of diosgenin extracted fromHeliyon · 2024Article
- Bioinspired Pyrano[2,3-Biomimetics (Basel, Switzerland) · 2024Article
- Synthesis, characterization and crystal structure of methyl 2-(2-oxo-2Acta crystallographica. Section E, Crystallographic communications · 2023Article
- Pharmacological Potential of Betulin as a Multitarget Compound.Biomolecules · 2023Review
- Design, Synthesis and Fungicidal Activity of Ester Derivatives of 4-(3,4-Dichloroisothiazole) 7-Hydroxy Coumarin.Molecules (Basel, Switzerland) · 2023Article
- Hogweed Seed Oil: Physico-Chemical Characterization, LC-MS Profile, and Neuroprotective Activity ofLife (Basel, Switzerland) · 2023Article
- Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review summarizes and systematizes the literature on the anti-HIV activity of plant coumarins with emphasis on isolation and the mechanism of their antiviral action. This review summarizes the information on the anti-HIV properties of simple coumarins as well as annulated furano- and pyranocoumarins and shows that coumarins of plant origin can act by several mechanisms: inhibition of HIV reverse transcriptase and integrase, inhibition of cellular factors that regulate HIV-1 replication, and transmission of viral particles from infected macrophages to healthy ones. It is important to note that some pyranocoumarins are able to act through several mechanisms or bind to several sites, which ensures the resistance of these compounds to HIV mutations. Here we review the last two decades of research on the anti-HIV activity of naturally occurring coumarins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.