Evidence map›Paper›PMID 36769117›Full record

ArticleInternational journal of molecular sciences2023

New Piperazine Derivatives of 6-Acetyl-7-hydroxy-4-methylcoumarin as 5-HT

Kinga Ostrowska, Anna Leśniak, Weronika Gryczka, Łukasz Dobrzycki, Magdalena Bujalska-Zadrożny, Bartosz Trzaskowski

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. HalogenatedRSC advances · 2025
    Article
  3. Exploring the Potential of Coumarin Derivatives on Serotonin Receptors 5-HTInternational journal of molecular sciences · 2025
    Article
  4. Article
  5. The Conjugates of Indolo[2,3-International journal of molecular sciences · 2024
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kinga OstrowskaDepartment of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Str., 02-097 Warsaw, Poland.ORCID 0000-0002-5990-646X
Anna LeśniakCentre for Preclinical Research and Technology, Department of Pharmacodynamics, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Str., 02-097 Warsaw, Poland.ORCID 0000-0002-6014-9208
Weronika GryczkaDepartment of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Str., 02-097 Warsaw, Poland.
Łukasz DobrzyckiCrystallochemistry Laboratory, Chemistry Department, Warsaw University, 1 Pasteura Str., 02-093 Warsaw, Poland.
Magdalena Bujalska-ZadrożnyCentre for Preclinical Research and Technology, Department of Pharmacodynamics, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Str., 02-097 Warsaw, Poland.
Bartosz TrzaskowskiCentre of New Technologies, University of Warsaw, 2C Banacha Str., 02-097 Warsaw, Poland.ORCID 0000-0003-2385-1476

Funding

Medical University of Warsaw, Faculty of Pharmacy FW24/F/PW2/N/20
6 · The paper itself

Abstract

A series of 15 new derivatives of 6-acetyl-7-hydroxy-4-methylcoumarin containing a piperazine group were designed with the help of computational methods and were synthesized to study their affinity for the serotonin 5-HT

Indexed as

Heterocyclic CompoundsSerotoninCoumarinsPiperazinesReceptor, Serotonin, 5-HT1AReceptor, Serotonin, 5-HT2AReceptors, SerotoninReceptors, Serotonin, 5-HT17-hydroxy-4-methylcoumarinCoumarinsHeterocyclic CompoundsPiperazinesReceptor, Serotonin, 5-HT1AReceptor, Serotonin, 5-HT2AReceptors, SerotoninReceptors, Serotonin, 5-HT1Serotonin6-acetyl-7-hydroxy-4-methylcoumarinCNS activitycrystal structurepiperazineserotonin receptors

Identifiers

PMID36769117
PMCPMC9917830

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.