Evidence map›Paper›PMID 36769065›Full record

SynthesisInternational journal of molecular sciences2023

Molecular and Biologic Effects of Platelet-Rich Plasma (PRP) in Ligament and Tendon Healing and Regeneration: A Systematic Review.

Byron Chalidis, Panagiotis Givissis, Pericles Papadopoulos, Charalampos Pitsilos

Registry-linked trialAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07456215 (The Effect of Platelet Rich Plasma), which is not on this map. Cited by 46 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07456215 phase1completednot on this map

The Effect of Platelet Rich Plasma (PRP) Application on Rotator Cuff Tear.

TypeinterventionalSponsorAristotle University Of ThessalonikiRan2022 to 2026Enrolled40ConditionsTendon Injuries, Supraspinatus Injury, PRPArmsPlatelet Rich Plasma, Normal saline
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Review
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  10. Investigation of the effects of acrylamide on tendon healing in rats.Acta orthopaedica et traumatologica turcica · 2026
    Article
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  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Byron Chalidis1st Orthopaedic Department, Aristotle University of Thessaloniki, 57010 Thessaloniki, Greece.ORCID 0000-0003-1305-2734
Panagiotis Givissis1st Orthopaedic Department, Aristotle University of Thessaloniki, 57010 Thessaloniki, Greece.ORCID 0000-0002-8649-1159
Pericles Papadopoulos2nd Orthopaedic Department, Aristotle University of Thessaloniki, 54635 Thessaloniki, Greece.
Charalampos Pitsilos2nd Orthopaedic Department, Aristotle University of Thessaloniki, 54635 Thessaloniki, Greece.ORCID 0000-0002-3091-866X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Platelet-rich plasma (PRP) has been introduced and applied to a wide spectrum of acute and chronic ligament and tendon pathologic conditions. Although the biological effect of PRP has been studied thoroughly in both animal and human studies, there is no consensus so far on the exact mechanism of its action as well as the optimal timing and dosage of its application. Therefore, we conducted a systematic review aiming to evaluate the molecular effect of the administration of PRP in tendoligamentous injuries and degenerative diseases. The literature search revealed 36 in vitro and in vivo studies examining the healing and remodeling response of animal and human ligament or tendon tissues to PRP. Platelet-rich plasma added in the culture media was highly associated with increased cell proliferation, migration, viability and total collagen production of both ligament- and tendon-derived cells in in vitro studies, which was further confirmed by the upregulation of collagen gene expression. In vivo studies correlated the PRP with higher fibroblastic anabolic activity, including increased cellularity, collagen production and vascularity of ligament tissue. Similarly, greater metabolic response of tenocytes along with the acceleration of the healing process in the setting of a tendon tear were noticed after PRP application, particularly between the third and fourth week after treatment. However, some studies demonstrated that PRP had no or even negative effect on tendon and ligament regeneration. This controversy is mainly related to the variable processes and methodologies of preparation of PRP, necessitating standardized protocols for both investigation and ap-plication.

Indexed as

Biological ProductsPlatelet-Rich PlasmaAnimalsCollagenHumansLigamentsTendonsBiological ProductsCollagenbiologycollagenligamentplatelet rich plasmaPRPtendon

Identifiers

PMID36769065
PMCPMC9917492

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.