Evidence map›Paper›PMID 36769047›Full record

ArticleInternational journal of molecular sciences2023

Antibody Conjugates Bispecific for Pollen Allergens and ICAM-1 with Potential to Prevent Epithelial Allergen Transmigration and Rhinovirus Infection.

Christina Weichwald, Ines Zettl, Isabella Ellinger, Katarzyna Niespodziana, Eva E Waltl, Sergio Villazala-Merino, Daniel Ivanov, Julia Eckl-Dorna, Verena Niederberger-Leppin, Rudolf Valenta and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Single-Domain Antibodies-Novel Tools to Study and Treat Allergies.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Christina WeichwaldDivision of Immunopathology, Institute for Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090 Vienna, Austria.
Ines ZettlDivision of Immunopathology, Institute for Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0003-2343-3012
Isabella EllingerDivision of Cellular and Molecular Pathophysiology, Institute for Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-6335-076X
Katarzyna NiespodzianaDivision of Immunopathology, Institute for Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0003-0700-965X
Eva E WaltlDepartment of Otorhinolaryngology, Medical University of Vienna, 1090 Vienna, Austria.
Sergio Villazala-MerinoDepartment of Otorhinolaryngology, Medical University of Vienna, 1090 Vienna, Austria.
Daniel IvanovDivision of Immunopathology, Institute for Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0003-1304-4224
Julia Eckl-DornaDepartment of Otorhinolaryngology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-5981-1607
Verena Niederberger-LeppinDepartment of Otorhinolaryngology, Medical University of Vienna, 1090 Vienna, Austria.
Rudolf ValentaDivision of Immunopathology, Institute for Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090 Vienna, Austria.
Sabine FlickerDivision of Immunopathology, Institute for Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0003-4768-8693

Funding

Danube Allergy Research Cluster, Country of Lower Austria P09FWF Austrian Science Fund F4607, F4613, P29398
6 · The paper itself

Abstract

Allergy and rhinovirus (RV) infections are major triggers for rhinitis and asthma, causing a socioeconomic burden. As RVs and allergens may act synergistically to promote airway inflammation, simultaneous treatment strategies for both causative agents would be innovative. We have previously identified the transmembrane glycoprotein intercellular adhesion molecule 1 (ICAM-1) as an anchor for antibody conjugates bispecific for ICAM-1 and

Indexed as

AllergensHypersensitivityImmunoglobulin EIntercellular Adhesion Molecule-1PhleumPlant ProteinsPoaceaePollenRhinovirusAllergensImmunoglobulin EIntercellular Adhesion Molecule-1Plant ProteinsallergenallergyantibodyICAM-1respiratory epitheliumrhinovirustopical treatment

Identifiers

PMID36769047
PMCPMC9917280

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.