Evidence map›Paper›PMID 36769009›Full record

ArticleInternational journal of molecular sciences2023

DNA Methylation of α-Synuclein Intron 1 Is Significantly Decreased in the Frontal Cortex of Parkinson's Individuals with

Adam R Smith, David M Richards, Katie Lunnon, Anthony H V Schapira, Anna Migdalska-Richards

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Epigenetic mechanisms of Parkinson's disease and potential epigenetic-based therapeutics.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  4. Epigenomic profile of GBA1 in Parkinson's disease.Parkinsonism & related disorders · 2025
    Article
  5. Article
  6. Review
  7. An Overview of Epigenetic Changes in the Parkinson's Disease Brain.International journal of molecular sciences · 2024
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Adam R SmithFaculty of Health and Life Sciences, University of Exeter, Exeter EX2 5DW, UK.ORCID 0000-0001-6495-2711
David M RichardsLiving Systems Institute, University of Exeter, Exeter EX4 4QD, UK.
Katie LunnonFaculty of Health and Life Sciences, University of Exeter, Exeter EX2 5DW, UK.
Anthony H V SchapiraDepartment of Clinical and Movement Neurosciences, University College London Queen Square Institute of Neurology, London NW3 2PF, UK.
Anna Migdalska-RichardsFaculty of Health and Life Sciences, University of Exeter, Exeter EX2 5DW, UK.
University of Exeter · GBNational Hospital for Neurology and Neurosurgery · GB

Funding

Medical Research Council MR/P022405/1Wellcome Trust 217561/Z/19/Z
6 · The paper itself

Abstract

Parkinson's disease (PD) is a common movement disorder, estimated to affect 4% of individuals by the age of 80. Mutations in the glucocerebrosidase 1 (

Indexed as

GlucosylceramidaseParkinson DiseaseAgedalpha-SynucleinDNA MethylationFrontal LobeHumansIntronsMutationalpha-SynucleinGlucosylceramidaseDNA hypomethylationDNA methylationepigeneticsGCaseglucocerebrosidase 1 (GBA1)Parkinson’s diseaseα-synuclein (SNCA)

Identifiers

PMID36769009
PMCPMC9917152
OpenAlexW4319795244

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.