Evidence map›Paper›PMID 36768995›Full record

ArticleInternational journal of molecular sciences2023

Myofilament Alterations Associated with Human R14del-Phospholamban Cardiomyopathy.

Mohit Kumar, Kobra Haghighi, Sheryl Koch, Jack Rubinstein, Francesca Stillitano, Roger J Hajjar, Evangelia G Kranias, Sakthivel Sadayappan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Mohit KumarDepartment of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Kobra HaghighiDepartment of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Sheryl KochDepartment of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Jack RubinsteinDepartment of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Francesca StillitanoDivision Heart and Lung, Department of Cardiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Roger J HajjarPhospholamban Heart Foundation, Postbus 66, 1775 ZH Middenmeer, The Netherlands.
Evangelia G KraniasDepartment of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Sakthivel SadayappanDepartment of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.ORCID 0000-0003-2006-7678
University of Cincinnati Medical Center · USUniversity Medical Center Utrecht · NL

Funding

Fast myosin binding protein-C and cardiac contractility in heart failureR01HL105826 · NHLBI · UNIVERSITY OF CINCINNATI · PI SADAYAPPAN, SAKTHIVEL · 2011 to 2025
$4.5M
Skeletal muscle sarcomere function in health and diseaseR01AR079477 · NIAMS · UNIVERSITY OF MINNESOTA · PI JOSEPH Mark METZGER · 2022 to 2026
$2.6M
Skeletal Myosin-Binding Protein C Regulation and Structural DynamicsR01AR079435 · NIAMS · UNIVERSITY OF ARIZONA · PI Brett A Colson · 2022 to 2026
$2.4M
Slow myosin binding protein-C in skeletal muscle physiologyR01AR078001 · NIAMS · UNIVERSITY OF CINCINNATI · PI SADAYAPPAN, SAKTHIVEL · 2020 to 2023
$1.8M
IGF-2R is a new therapeutic target for cardiac ischemia-reperfusion injuryR01HL143490 · NHLBI · UNIVERSITY OF CINCINNATI · PI WANG, YIGANG · 2019 to 2022
$1.6M
Stimulating Access to Research in the University of Cincinnati Internal Medicine Residency ProgramR38HL155775 · NHLBI · UNIVERSITY OF CINCINNATI · PI Jack Rubinstein · 2021 to 2026
$1.6M
Molecular mechanism of hypertrophic cardiomyopathy in populations of South Asian descendantsR01HL130356 · NHLBI · UNIVERSITY OF CINCINNATI · PI SADAYAPPAN, SAKTHIVEL · 2016 to 2019
$1.6M
NHLBI NIH HHS R01 HL105826NHLBI NIH HHS R01 HL130356NHLBI NIH HHS R01 HL143490NHLBI NIH HHS R38 HL155775NIAMS NIH HHS R01 AR078001NIAMS NIH HHS R01 AR079435NIAMS NIH HHS R01 AR079477
6 · The paper itself

Abstract

Phospholamban (

Indexed as

CardiomyopathiesMyofibrilsAnimalsArrhythmias, CardiacCalciumCalcium-Binding ProteinsHumansMicePhospholambanUreaCalciumCalcium-Binding Proteinsomecamtiv mecarbilPhospholambanUreacontractilityfemalesmalesmyofilamentsomecamtiv mecarbilR14del-phospholamban

Identifiers

PMID36768995
PMCPMC9917359
OpenAlexW4318595441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.