Evidence map›Paper›PMID 36768965›Full record

ArticleInternational journal of molecular sciences2023

Investigating Therapeutic Effects of Indole Derivatives Targeting Inflammation and Oxidative Stress in Neurotoxin-Induced Cell and Mouse Models of Parkinson's Disease.

Ya-Jen Chiu, Chih-Hsin Lin, Chung-Yin Lin, Pei-Ning Yang, Yen-Shi Lo, Yu-Chieh Chen, Chiung-Mei Chen, Yih-Ru Wu, Ching-Fa Yao, Kuo-Hsuan Chang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Heterocyclic Derivatives in Parkinson's Therapy: Recent Advances and Prospects.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2026
    Review
  5. Review
  6. Sleep Disorders in Climacteric Women: Glutathione, Glutathione S-Transferase P1 and Gut Microbiome Interrelation.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025
    Article
  7. Article
  8. Article
  9. From Stress to Synapse: The Neuronal Atrophy Pathway to Mood Dysregulation.International journal of molecular sciences · 2025
    Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Impact of NQO1 dysregulation in CNS disorders.Journal of translational medicine · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ya-Jen ChiuDepartment of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.ORCID 0000-0003-3195-2509
Chih-Hsin LinDepartment of Neurology, Chang Gung Memorial Hospital, School of Medicine, Chang Gung University, Taoyuan 33305, Taiwan.
Chung-Yin LinMedical Imaging Research Center, Institute for Radiological Research, Chang Gung University/Chang Gung Memorial Hospital, Taoyuan 33302, Taiwan.
Pei-Ning YangDepartment of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.
Yen-Shi LoDepartment of Neurology, Chang Gung Memorial Hospital, School of Medicine, Chang Gung University, Taoyuan 33305, Taiwan.
Yu-Chieh ChenDepartment of Neurology, Chang Gung Memorial Hospital, School of Medicine, Chang Gung University, Taoyuan 33305, Taiwan.
Chiung-Mei ChenDepartment of Neurology, Chang Gung Memorial Hospital, School of Medicine, Chang Gung University, Taoyuan 33305, Taiwan.ORCID 0000-0002-0769-0353
Yih-Ru WuDepartment of Neurology, Chang Gung Memorial Hospital, School of Medicine, Chang Gung University, Taoyuan 33305, Taiwan.
Ching-Fa YaoDepartment of Chemistry, National Taiwan Normal University, Taipei 11677, Taiwan.
Kuo-Hsuan ChangDepartment of Neurology, Chang Gung Memorial Hospital, School of Medicine, Chang Gung University, Taoyuan 33305, Taiwan.ORCID 0000-0003-4972-9823
Guey-Jen Lee-ChenDepartment of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.ORCID 0000-0003-4818-9917

Funding

Chang Gung Medical Foundation CMRPG3L0891-2Ministry of Science and Technology, Taiwan MOST 110-2320-B-003-007, 109-2811-B-003-503, 110-2811-B-003-504 and 111-2314-B-182-053
6 · The paper itself

Abstract

Neuroinflammation and oxidative stress have been emerging as important pathways contributing to Parkinson's disease (PD) pathogenesis. In PD brains, the activated microglia release inflammatory factors such as interleukin (IL)-β, IL-6, tumor necrosis factor (TNF)-α, and nitric oxide (NO), which increase oxidative stress and mediate neurodegeneration. Using 1-methyl-4-phenylpyridinium (MPP

Indexed as

Parkinson Disease1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine1-Methyl-4-phenylpyridiniumAnimalsDisease Models, AnimalHumansInflammationInterleukin-6MiceMice, Inbred C57BLMicrogliaNeuroinflammatory DiseasesNeurotoxinsNLR Family, Pyrin Domain-Containing 3 ProteinOxidative StressTumor Necrosis Factor-alpha1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine1-Methyl-4-phenylpyridiniumInterleukin-6NeurotoxinsNLR Family, Pyrin Domain-Containing 3 ProteinTumor Necrosis Factor-alphaMPP+ HMC3 cell modelMPTP mouse modelneuroinflammationNLRP3 inflammasomeoxidative stressParkinson’s diseasetherapeutics

Identifiers

PMID36768965
PMCPMC9917106

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.