ReviewInternational journal of molecular sciences2023
Coenzyme Q10 Metabolism: A Review of Unresolved Issues.
Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Bioavailability and Cellular Compatibility of a Novel Coenzyme QEuropean journal of drug metabolism and pharmacokinetics · 2026Trial
- Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.Trials · 2024Trial
- Integrated multi-omics unravels solanesol's multi-organ protection mechanisms against insulin resistance in type 2 diabetic mice.Journal of advanced research · 2026Article
- A founder variant in TANGO2 p.(Leu148Trp) in ten Palestinian families: clinical characterization and haplotype analysis of TANGO2 deficiency disorder.BMC medical genomics · 2026Article
- Effects of coenzyme Q10 on growth performance, rumen fermentation, blood metabolites, antioxidant status, and immune responses of pre-weaned Holstein dairy calves.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Comparative review of translational approaches in lipid-based and water-based encapsulation strategies for coenzyme Q10.Drug delivery and translational research · 2026Review
- Coq4 deficiency induces placental vascular development defects through FSP1/CoQ10 axis-mediated endothelial ferroptosis.Frontiers in cell and developmental biology · 2026Article
- Blood-Brain Barrier and Neuronal Model Systems for Studying CoQAntioxidants (Basel, Switzerland) · 2025Review
- Coenzyme Q10 Ameliorates Fibromyalgia-like Symptoms and Cognitive Deficits by Enhancing Hippocampal PGC-1α/FNDC5/BDNF Pathway in Reserpine-Treated Rats.Molecular neurobiology · 2025Article
- MQPD: An Antioxidant Quinone-Dopamine Hybrid Which Induces Sustained Brain Dopamine Elevation.Antioxidants (Basel, Switzerland) · 2025Article
- Protective role of coenzyme Q10 against renal and hepatic toxicity induced by acetaminophen overdose in albino rats.Open veterinary journal · 2025Article
- Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies.Annals of neurology · 2025Review
- Coenzyme Q10 and Obesity: An Overview.Antioxidants (Basel, Switzerland) · 2025Review
- Traumatic Brain Injury and Coenzyme Q10: An Overview.International journal of molecular sciences · 2025Review
- Coenzyme Q10 microemulsion ion-activated gel: a promising ophthalmic delivery system for enhanced corneal protection and sustained release.BMC pharmacology & toxicology · 2025Article
- Coenzyme Q10 and the Blood-Brain Barrier: An Overview.Journal of clinical medicine · 2025Review
- Subacute Cardiomyopathy Due to Statin Treatment: Can It Be True?-Case Report and Literature Review.Life (Basel, Switzerland) · 2025Article
- Spatial mapping of dextran sodium sulphate-induced intestinal inflammation and its systemic effects.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Current global vitamin and cofactor prescribing practices for primary mitochondrial diseases: Results of a European reference network survey.Journal of inherited metabolic disease · 2025Article
- Understanding coenzyme Q.Physiological reviews · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The variable success in the outcome of randomised controlled trials supplementing coenzyme Q10 (CoQ10) may in turn be associated with a number of currently unresolved issues relating to CoQ10 metabolism. In this article, we have reviewed what is currently known about these factors and where gaps in knowledge exist that need to be further elucidated. Issues addressed include (i) whether the bioavailability of CoQ10 could be improved; (ii) whether CoQ10 could be administered intravenously; (iii) whether CoQ10 could be administered via alternative routes; (iv) whether CoQ10 can cross the blood-brain barrier; (v) how CoQ10 is transported into and within target cells; (vi) why some clinical trials supplementing CoQ10 may have been unsuccessful; and (vii) which is the most appropriate tissue for the clinical assessment of CoQ10 status.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.