Evidence map›Paper›PMID 36768889›Full record

ArticleInternational journal of molecular sciences2023

Spatially Resolved Molecular Approaches for the Characterisation of Non-Invasive Follicular Tumours with Papillary-like Features (NIFTPs).

Isabella Piga, Vincenzo L'Imperio, Lucrezia Principi, Claudio Bellevicine, Nicola Fusco, Fausto Maffini, Konstantinos Venetis, Mariia Ivanova, Davide Seminati, Gabriele Casati and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Isabella PigaClinical Proteomics and Metabolomics Unit, Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0001-8221-2493
Vincenzo L'ImperioDepartment of Medicine and Surgery, Pathology, University of Milan-Bicocca, IRCCS Fondazione San Gerardo dei Tintori, 20900 Monza, Italy.ORCID 0000-0002-9284-2998
Lucrezia PrincipiClinical Proteomics and Metabolomics Unit, Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0002-0391-7995
Claudio BellevicineDepartment of Public Health, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0002-7479-6457
Nicola FuscoDivision of Pathology, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.ORCID 0000-0002-9101-9131
Fausto MaffiniDivision of Pathology, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.ORCID 0000-0002-4554-8956
Konstantinos VenetisDivision of Pathology, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.
Mariia IvanovaDivision of Pathology, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.ORCID 0000-0002-7636-1000
Davide SeminatiDepartment of Medicine and Surgery, Pathology, University of Milan-Bicocca, IRCCS Fondazione San Gerardo dei Tintori, 20900 Monza, Italy.ORCID 0000-0002-2166-301X
Gabriele CasatiDepartment of Medicine and Surgery, Pathology, University of Milan-Bicocca, IRCCS Fondazione San Gerardo dei Tintori, 20900 Monza, Italy.
Lisa PaganiClinical Proteomics and Metabolomics Unit, Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0002-9870-932X
Stefania GalimbertiBicocca Bioinformatics Biostatistics and Bioimaging B4 Center, Department of Medicine and Surgery, University of Milan-Bicocca (UNIMIB), 20900 Monza, Italy.ORCID 0000-0003-1504-7242
Giulia CapitoliBicocca Bioinformatics Biostatistics and Bioimaging B4 Center, Department of Medicine and Surgery, University of Milan-Bicocca (UNIMIB), 20900 Monza, Italy.ORCID 0000-0002-8178-2440
Mattia GaranciniHPB and Gastroenterological Surgery Unit, Department of Surgery, IRCCS Fondazione San Gerardo dei Tintori, 20900 Monza, Italy.
Andrea-Valer GattiHPB and Gastroenterological Surgery Unit, Department of Surgery, IRCCS Fondazione San Gerardo dei Tintori, 20900 Monza, Italy.
Fulvio MagniClinical Proteomics and Metabolomics Unit, Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0002-8663-0374
Fabio PagniDepartment of Medicine and Surgery, Pathology, University of Milan-Bicocca, IRCCS Fondazione San Gerardo dei Tintori, 20900 Monza, Italy.ORCID 0000-0001-9625-1637

Funding

Ministero della Salute Ricerca Finalizzata 2019
6 · The paper itself

Abstract

Noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP) are low-risk thyroid lesions most often characterised by RAS-type mutations. The histological diagnosis may be challenging, and even immunohistochemistry and molecular approaches have not yet provided conclusive solutions. This study characterises a set of NIFTPs by Matrix-Assisted Laser Desorption/Ionisation (MALDI)-Mass Spectrometry Imaging (MSI) to highlight the proteomic signatures capable of overcoming histological challenges. Archived formalin-fixed paraffin-embedded samples from 10 NIFTPs (

Indexed as

Adenocarcinoma, FollicularThyroid NeoplasmsHumansProteomicsSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationMALDI–MSINGSNIFTPproteomicsthyroid cancer

Identifiers

PMID36768889
PMCPMC9916790

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.