Evidence map›Paper›PMID 36768885›Full record

ArticleInternational journal of molecular sciences2023

Antiproliferative Activity of Antibiotics through DNA Binding Mechanism: Evaluation and Molecular Docking Studies.

Alexandros-Dimitrios C Magklaras, Christina N Banti, Sotiris K Hadjikakou

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alexandros-Dimitrios C MagklarasLaboratory of Biological Inorganic Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece.
Christina N BantiLaboratory of Biological Inorganic Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece.ORCID 0000-0001-6727-2711
Sotiris K HadjikakouLaboratory of Biological Inorganic Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece.ORCID 0000-0001-9556-6266

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The antiproliferative activity of three antibiotics clinically use, was studied through DNA inhibition mechanisms, ex vivo, in silico and in vitro. The ex vivo interaction of DNA with ciprofloxacin hydrochloride (

Indexed as

Anti-Bacterial AgentsAntineoplastic AgentsCell ProliferationCiprofloxacinDNADoxorubicinHumansMCF-7 CellsMolecular Docking SimulationMolecular StructureAnti-Bacterial AgentsAntineoplastic AgentsCiprofloxacinDNADoxorubicinantibioticsantitumor activitybiological inorganic chemistryDNA binding studiesstructure activity relationship (SAR)

Identifiers

PMID36768885
PMCPMC9916907

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.