ReviewInternational journal of molecular sciences2023
HLA-G and Recurrent Pregnancy Loss.
Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Biomarker role of maternal soluble human leukocyte antigen G in pre-eclampsia: A meta-analysis.Immunity, inflammation and disease · 2024Pooled it
- Effect of vitamin D adjuvant therapy on the proportion of regulatory T cells in peripheral blood and pregnancy outcome of patients with recurrent miscarriage.The journal of obstetrics and gynaecology research · 2025Trial
- Long non-coding RNA gene polymorphisms and risk of recurrent pregnancy loss: a meta-analysis.Journal of assisted reproduction and genetics · 2026Review
- Is the HLA System Really Involved in Implantation, Pregnancy, or Abortion of the Fetus?: Strengths, Weaknesses, and Controversial Points.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Review
- Epigenetic regulation of HLA-G : implications for recurrent pregnancy loss.Molecular biology reports · 2026Article
- Article
- HLA-G, IL-6 and TGF-β in Seminal Plasma as Potential Biomarkers of ART Outcome.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025Article
- Homozygous AA Genotype of IL-17A and 14-bp Insertion Polymorphism in HLA-G 3'UTR Are Associated with Increased Risk of Gestational Diabetes Mellitus.International journal of environmental research and public health · 2025Article
- Analyzing the impact of human leukocyte antigen mismatch on the incidence of prostate cancer and the advantage of T cell therapy in patients after kidney transplantation based on the United Network for Organ Sharing database.Frontiers in oncology · 2025Article
- Classification and Hemodynamic Characteristics of Uterine Artery Blood Flow in Recurrent Spontaneous Abortion.Current medical imaging · 2025Article
- Ralationship between polymorphisms and diplotypes of HLA-G 3'UTR and fetuses with abnormal chromosomes or unexplained pregnancy loss (UPL).Human genomics · 2024Article
- HLA-G high-expressor 3'UTR markers are linked to gastric cancer development and survival.Cancer immunology, immunotherapy : CII · 2024Article
- A Comprehensive Review of Advanced Diagnostic Techniques for Endometriosis: New Approaches to Improving Women's Well-Being.Medicina (Kaunas, Lithuania) · 2024Review
- PGRMC2 and HLA-G regulate immune homeostasis in a microphysiological model of human maternal-fetal membrane interface.Communications biology · 2024Article
- How the Soluble Human Leukocyte Antigen-G levels in Amniotic Fluid and Maternal Serum Correlate with the Feto-Placental Growth in Uncomplicated Pregnancies.Bioengineering (Basel, Switzerland) · 2024Article
- Maternal-Fetal Compatibility in Recurrent Pregnancy Loss.Journal of clinical medicine · 2024Review
- Phenotypic characterisation of regulatory T cells in patients with gestational diabetes mellitus.Scientific reports · 2024Article
- Predictive Capabilities of Human Leukocyte Antigen-G and Galectin-13 Levels in the Amniotic Fluid and Maternal Blood for the Pregnancy Outcome.Medicina (Kaunas, Lithuania) · 2024Article
- Metabolomic analysis reveals potential role of immunometabolism dysregulation in recurrent pregnancy loss.Frontiers in endocrinology · 2024Article
- TNF-α-positive patients with recurrent pregnancy loss: The etiology and management.Technology and health care : official journal of the European Society for Engineering and Medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Placentation is an immunological compromise where maternal immune system cells and trophoblastic cells interact to reach an equilibrium condition. Although the cross talk between the two systems is complex and not completely understood, Human Leukocyte Antigen G (HLA-G), expressed on trophoblastic cell surfaces, seems to be one of the main molecules involved in the modulation of both local and systemic maternal immune response. The prevalence of recurrent pregnancy loss (RPL), probably underestimated, is 5% of all women who achieve pregnancy, and about 40-60% percent of RPL cases are unexplained. There is an immunological analogy between allograft rejection and miscarriage, and the purpose of this review is to describe how the HLA-G pathway alterations are involved in disrupting the immunologic balance and in increasing the risk of recurrent pregnancy loss.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.