Evidence map›Paper›PMID 36768810›Full record

ArticleInternational journal of molecular sciences2023

Comparison of Tandem Mass Spectrometry and the Fluorometric Method-Parallel Phenylalanine Measurement on a Large Fresh Sample Series and Implications for Newborn Screening for Phenylketonuria.

Dasa Perko, Urh Groselj, Vanja Cuk, Ziga Iztok Remec, Mojca Zerjav Tansek, Ana Drole Torkar, Blaz Krhin, Ajda Bicek, Adrijana Oblak, Tadej Battelino and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Current Status of Newborn Screening in Southeastern and Central Europe.International journal of neonatal screening · 2026
    Article
  2. International Survey on Phenylketonuria Newborn Screening.International journal of neonatal screening · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Fast Label-Free Metabolic Profile Recognition Identifies Phenylketonuria and Subtypes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dasa PerkoClinical Institute for Special Laboratory Diagnostics, University Children's Hospital, UMC Ljubljana, 1000 Ljubljana, Slovenia.ORCID 0000-0002-6184-5627
Urh GroseljDepartment of Endocrinology, Diabetes and Metabolic Diseases, University Children's Hospital, UMC Ljubljana, 1000 Ljubljana, Slovenia.ORCID 0000-0002-5246-9869
Vanja CukClinical Institute for Special Laboratory Diagnostics, University Children's Hospital, UMC Ljubljana, 1000 Ljubljana, Slovenia.
Ziga Iztok RemecClinical Institute for Special Laboratory Diagnostics, University Children's Hospital, UMC Ljubljana, 1000 Ljubljana, Slovenia.
Mojca Zerjav TansekDepartment of Endocrinology, Diabetes and Metabolic Diseases, University Children's Hospital, UMC Ljubljana, 1000 Ljubljana, Slovenia.
Ana Drole TorkarDepartment of Endocrinology, Diabetes and Metabolic Diseases, University Children's Hospital, UMC Ljubljana, 1000 Ljubljana, Slovenia.
Blaz KrhinDepartment of Nuclear Medicine, UMC Ljubljana, 1000 Ljubljana, Slovenia.
Ajda BicekDepartment of Nuclear Medicine, UMC Ljubljana, 1000 Ljubljana, Slovenia.
Adrijana OblakDepartment of Nuclear Medicine, UMC Ljubljana, 1000 Ljubljana, Slovenia.ORCID 0000-0003-3105-2746
Tadej BattelinoDepartment of Endocrinology, Diabetes and Metabolic Diseases, University Children's Hospital, UMC Ljubljana, 1000 Ljubljana, Slovenia.
Barbka Repic LampretClinical Institute for Special Laboratory Diagnostics, University Children's Hospital, UMC Ljubljana, 1000 Ljubljana, Slovenia.

Funding

Slovenian Research Agency P3-0343
6 · The paper itself

Abstract

Phenylketonuria (PKU) was the first disease to be identified by the newborn screening (NBS) program. Currently, there are various methods for determining phenylalanine (Phe) values, with tandem mass spectrometry (MS/MS) being the most widely used method worldwide. We aimed to compare the MS/MS method with the fluorometric method (FM) for measuring Phe in the dried blood spot (DBS) and the efficacy of both methods in the NBS program. The FM was performed using a neonatal phenylalanine kit and a VICTOR2

Indexed as

Neonatal ScreeningPhenylketonuriasFluorometryHumansInfant, NewbornPhenylalanineTandem Mass SpectrometryPhenylalaninecomparisonfalse positivefluorometric method (FM)newborn screening (NBS)phenylalanine (Phe)phenylketonuria (PKU)recall ratetandem mass spectrometry (MS/MS)

Identifiers

PMID36768810
PMCPMC9916910

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.