Evidence map›Paper›PMID 36768796›Full record

ArticleInternational journal of molecular sciences2023

The Comprehensive Steroidome in Complete TSPO/PBR Knockout Mice under Basal Conditions.

Philippe Liere, Guo-Jun Liu, Antoine Pianos, Ryan J Middleton, Richard B Banati, Yvette Akwa

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. The Effects of Neuroactive Steroids on Myelin in Health and Disease.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2024
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Philippe LiereDisease and Hormones of the Nervous System, U1195 Inserm-Université Paris Saclay, 80 rue du Général Leclerc, 94276 Kremlin-Bicêtre, France.ORCID 0000-0001-9603-0586
Guo-Jun LiuAustralian Nuclear Science and Technology Organisation (ANSTO), Kirrawee, NSW 2232, Australia.ORCID 0000-0002-4278-8372
Antoine PianosDisease and Hormones of the Nervous System, U1195 Inserm-Université Paris Saclay, 80 rue du Général Leclerc, 94276 Kremlin-Bicêtre, France.ORCID 0000-0001-5417-5429
Ryan J MiddletonAustralian Nuclear Science and Technology Organisation (ANSTO), Kirrawee, NSW 2232, Australia.ORCID 0000-0001-8024-7772
Richard B BanatiAustralian Nuclear Science and Technology Organisation (ANSTO), Kirrawee, NSW 2232, Australia.
Yvette AkwaDisease and Hormones of the Nervous System, U1195 Inserm-Université Paris Saclay, 80 rue du Général Leclerc, 94276 Kremlin-Bicêtre, France.ORCID 0000-0003-2181-4612

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The 18 kDa translocator protein (TSPO/PBR) is a multifunctional evolutionary highly conserved outer mitochondrial membrane protein. Decades of research has reported an obligatory role of TSPO/PBR in both mitochondrial cholesterol transport and, thus, steroid production. However, the strict dependency of steroidogenesis on TSPO/PBR has remained controversial. The aim of this study was to provide insight into the steroid profile in complete C57BL/6-

Indexed as

Receptors, GABATandem Mass SpectrometryAnimalsCarrier ProteinsMaleMiceMice, Inbred C57BLMice, KnockoutPregnenoloneSteroidsCarrier ProteinsPregnenoloneReceptors, GABASteroidsendocrine glandsgas chromatography–tandem mass spectrometrygene knockoutmitochondrianeurosteroidsPBRperipheral benzodiazepine receptorsteroidogenesistranslocator proteinTSPO

Identifiers

PMID36768796
PMCPMC9916858

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.