Evidence map›Paper›PMID 36768705›Full record

ArticleInternational journal of molecular sciences2023

Gut Microbiome Composition in Dystonia Patients.

Elze R Timmers, J Casper Swarte, Ranko Gacesa, Johannes R Björk, Rinse K Weersma, Marina A J Tijssen, Tom J de Koning, Hermie J M Harmsen, Klary E Niezen-Koning

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Observational
  2. The Gut Microbiota Regulates Motor Deficits via Butyrate in a GnalAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Elze R TimmersDepartment of Neurology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.
J Casper SwarteDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.ORCID 0000-0002-3709-9193
Ranko GacesaDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.ORCID 0000-0003-2119-0539
Johannes R BjörkDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.
Rinse K WeersmaDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.
Marina A J TijssenDepartment of Neurology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.
Tom J de KoningExpertise Center Movement Disorders Groningen, University Medical Center Groningen, 9700RB Groningen, The Netherlands.
Hermie J M HarmsenDepartment of Medical Microbiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.ORCID 0000-0003-2725-6148
Klary E Niezen-KoningExpertise Center Movement Disorders Groningen, University Medical Center Groningen, 9700RB Groningen, The Netherlands.ORCID 0000-0002-9384-4354

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dystonia is a movement disorder in which patients have involuntary abnormal movements or postures. Non-motor symptoms, such as psychiatric symptoms, sleep problems and fatigue, are common. We hypothesise that the gut microbiome might play a role in the pathophysiology of the (non-)motor symptoms in dystonia via the gut-brain axis. This exploratory study investigates the composition of the gut microbiome in dystonia patients compared to healthy controls. Furthermore, the abundance of neuro-active metabolic pathways, which might be implicated in the (non-)motor symptoms, was investigated. We performed both metagenomic and 16S rRNA sequencing on the stool samples of three subtypes of dystonia (27 cervical dystonia, 20 dopa-responsive dystonia and 24 myoclonus-dystonia patients) and 25 controls. While microbiome alpha and beta diversity was not different between dystonia patients and controls, dystonia patients had higher abundances of

Indexed as

DyskinesiasDystoniaDystonic DisordersGastrointestinal MicrobiomeMental DisordersHumansRNA, Ribosomal, 16SRNA, Ribosomal, 16Sdystoniagut–brain axisgut microbiome

Identifiers

PMID36768705
PMCPMC9916458

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.