Evidence map›Paper›PMID 36768686›Full record

ReviewInternational journal of molecular sciences2023

Immunotherapy for Hepatocellular Carcinoma in the Setting of Liver Transplantation: A Review.

Zurabi Lominadze, Kareen Hill, Mohammed Rifat Shaik, Justin P Canakis, Mohammad Bourmaf, Cyrus Adams-Mardi, Ameer Abutaleb, Lopa Mishra, Kirti Shetty

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zurabi LominadzeDivision of Gastroenterology & Hepatology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0003-3808-496X
Kareen HillDepartment of Medicine, University of Maryland Medical Center, Baltimore, MD 21201, USA.
Mohammed Rifat ShaikDepartment of Medicine, University of Maryland Medical Center Midtown Campus, Baltimore, MD 21201, USA.
Justin P CanakisDepartment of Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA.
Mohammad BourmafDepartment of Medicine, University of Maryland Medical Center, Baltimore, MD 21201, USA.
Cyrus Adams-MardiDepartment of Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA.
Ameer AbutalebDepartment of Surgery, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA.
Lopa MishraCold Spring Harbor Laboratory, Feinstein Institutes for Medical Research, Division of Gastroenterology and Hepatology, Northwell Health, Manhasset, NY 11030, USA.
Kirti ShettyDivision of Gastroenterology & Hepatology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Funding

Role of Beta Spectrin and Smad in Alcohol-Induced Liver and GI Cell ProliferationR01AA023146 · NIAAA · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Lopa Mishra · 2013 to 2026
$4.6M
Pathway Specific Functional Biomarkers for the Early Detection of Liver CancerU01CA230690 · NCI · GEORGE WASHINGTON UNIVERSITY · PI MISHRA, LOPA, SHETTY, KIRTI · 2018 to 2022
$3.4M
Cellular interactions between TGF-beta pathway members and epignetic regulators in liver and gastrointestinal cancersR01CA236591 · NCI · GEORGE WASHINGTON UNIVERSITY · PI Jian Chen, Lopa Mishra · 2018 to 2026
$3.0M
NCI NIH HHS R01 CA236591NCI NIH HHS U01 CA230690NIAAA NIH HHS R01 AA023146
6 · The paper itself

Abstract

The emerging field of immuno-oncology has brought exciting developments in the treatment of hepatocellular carcinoma (HCC). It has also raised urgent questions about the role of immunotherapy in the setting of liver transplantation, both before and after transplant. A growing body of evidence points to the safety and efficacy of immunotherapeutic agents as potential adjuncts for successful down-staging of advanced HCCs to allow successful transplant in carefully selected patients. For patients with recurrent HCC post-transplant, immunotherapy has a limited, yet growing role. In this review, we describe optimal regimens in the setting of liver transplantation.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsLiver TransplantationHumansImmunotherapyallograft rejectionhepatocellular carcinomaimmunotherapyliver transplantation

Identifiers

PMID36768686
PMCPMC9917203

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.