Evidence map›Paper›PMID 36768650›Full record

ArticleInternational journal of molecular sciences2023

Release of HMGB1 and Toll-like Receptors 2, 4, and 9 Signaling Are Modulated by

Igor Splichal, Sharon M Donovan, Zdislava Kindlova, Zbynek Stranak, Vera Neuzil Bunesova, Marek Sinkora, Katerina Polakova, Barbora Valaskova, Alla Splichalova

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Porcine intestinal goblet cells: Guardians of mucosal immunity and barrier function.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026
    Review
  2. Review
  3. Article
  4. Understanding the probiotic health benefits ofFrontiers in microbiology · 2025
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Igor SplichalLaboratory of Gnotobiology, Institute of Microbiology, Czech Academy of Sciences, 549 22 Novy Hradek, Czech Republic.ORCID 0000-0003-3665-1377
Sharon M DonovanDepartment of Food Science and Human Nutrition, University of Illinois, Urbana, IL 61801, USA.ORCID 0000-0002-9785-4189
Zdislava KindlovaLaboratory of Gnotobiology, Institute of Microbiology, Czech Academy of Sciences, 549 22 Novy Hradek, Czech Republic.
Zbynek StranakDepartment of Neonatology, Institute for the Care of Mother and Child, 147 00 Prague, Czech Republic.ORCID 0000-0001-7095-3198
Vera Neuzil BunesovaDepartment of Microbiology, Nutrition and Dietetics, Czech University of Life Sciences in Prague, 160 00 Prague, Czech Republic.ORCID 0000-0002-7596-4360
Marek SinkoraLaboratory of Gnotobiology, Institute of Microbiology, Czech Academy of Sciences, 549 22 Novy Hradek, Czech Republic.
Katerina PolakovaLaboratory of Gnotobiology, Institute of Microbiology, Czech Academy of Sciences, 549 22 Novy Hradek, Czech Republic.
Barbora ValaskovaLaboratory of Gnotobiology, Institute of Microbiology, Czech Academy of Sciences, 549 22 Novy Hradek, Czech Republic.ORCID 0000-0002-5791-6349
Alla SplichalovaLaboratory of Gnotobiology, Institute of Microbiology, Czech Academy of Sciences, 549 22 Novy Hradek, Czech Republic.ORCID 0000-0002-7428-7687
Czech Academy of Sciences · CZCzech University of Life Sciences Prague · CZUniversity of Illinois Urbana-Champaign · USÚstav pro Péči o Matku a Dítě · CZ

Funding

Czech Science Foundation 13-14736SCzech Science Foundation 20-03282S
6 · The paper itself

Abstract

Gnotobiotic (GN) animals with defined microbiota allow us to study host-microbiota and microbiota-microbiota interferences. Preterm germ-free (GF) piglets were mono-associated with probiotic

Indexed as

Bifidobacterium animalisHMGB1 ProteinProbioticsAnimalsGerm-Free LifeHumansInfant, NewbornInfant, PrematureSalmonella typhimuriumSwineToll-Like ReceptorsHMGB1 ProteinToll-Like ReceptorsBifidobacterium animalis subsp. lactis BB-12high mobility group box 1immunodeficient hostinflammatory cytokinesintestinal barriermucinSalmonella Typhimuriumtight junction proteinsToll-like receptors

Identifiers

PMID36768650
PMCPMC9916534
OpenAlexW4317932773

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.