Evidence map›Paper›PMID 36768625›Full record

ArticleInternational journal of molecular sciences2023

Knockdown of Amyloid Precursor Protein Increases Ion Channel Expression and Alters Ca

Maria Paschou, Danai Liaropoulou, Vasileia Kalaitzaki, Spiros Efthimiopoulos, Panagiota Papazafiri

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. IPAntioxidants (Basel, Switzerland) · 2024
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maria PaschouDivision of Animal and Human Physiology, Department of Biology, National and Kapodistrian University of Athens, 15784 Athens, Greece.
Danai LiaropoulouDivision of Animal and Human Physiology, Department of Biology, National and Kapodistrian University of Athens, 15784 Athens, Greece.
Vasileia KalaitzakiDivision of Animal and Human Physiology, Department of Biology, National and Kapodistrian University of Athens, 15784 Athens, Greece.
Spiros EfthimiopoulosDivision of Animal and Human Physiology, Department of Biology, National and Kapodistrian University of Athens, 15784 Athens, Greece.
Panagiota PapazafiriDivision of Animal and Human Physiology, Department of Biology, National and Kapodistrian University of Athens, 15784 Athens, Greece.

Funding

General Secretariat of Research and Technology, Greece ARISTEIASpecial Research Account of the National and Kapodistrian University of Athens 18122
6 · The paper itself

Abstract

Although the physiological role of the full-length Amyloid Precursor Protein (APP) and its proteolytic fragments remains unclear, they are definitively crucial for normal synaptic function. Herein, we report that the downregulation of APP in SH-SY5Y cells, using short hairpin RNA (shRNA), alters the expression pattern of several ion channels and signaling proteins that are involved in synaptic and Ca

Indexed as

Amyloid beta-Protein PrecursorNeuroblastomaCalciumCalcium SignalingEndoplasmic ReticulumHumansInositol 1,4,5-Trisphosphate ReceptorsRyanodine Receptor Calcium Release ChannelAmyloid beta-Protein PrecursorCalciumInositol 1,4,5-Trisphosphate ReceptorsRyanodine Receptor Calcium Release Channelampa receptorsamyloid precursor proteinCa2+ signalinginositol 1,4,5-triphosphate receptorsp-AKTryanodine receptorsSTIM1

Identifiers

PMID36768625
PMCPMC9917207

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.