Evidence map›Paper›PMID 36768553›Full record

ArticleInternational journal of molecular sciences2023

Association of GILZ with MUC2, TLR2, and TLR4 in Inflammatory Bowel Disease.

Luigi Cari, Lucrezia Rosati, Giuseppe Leoncini, Eleonora Lusenti, Marco Gentili, Giuseppe Nocentini, Carlo Riccardi, Graziella Migliorati, Simona Ronchetti

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Luigi CariPharmacology Division, Department of Medicine and Surgery, University of Perugia, P.le L. Severi 1, 06132 Perugia, Italy.ORCID 0000-0003-0698-3872
Lucrezia RosatiPharmacology Division, Department of Medicine and Surgery, University of Perugia, P.le L. Severi 1, 06132 Perugia, Italy.
Giuseppe LeonciniFirst Pathology Division, Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G. Venezian 1, 20133 Milano, Italy.
Eleonora LusentiPharmacology Division, Department of Medicine and Surgery, University of Perugia, P.le L. Severi 1, 06132 Perugia, Italy.
Marco GentiliPharmacology Division, Department of Medicine and Surgery, University of Perugia, P.le L. Severi 1, 06132 Perugia, Italy.ORCID 0000-0002-2305-4488
Giuseppe NocentiniPharmacology Division, Department of Medicine and Surgery, University of Perugia, P.le L. Severi 1, 06132 Perugia, Italy.ORCID 0000-0002-5209-0488
Carlo RiccardiPharmacology Division, Department of Medicine and Surgery, University of Perugia, P.le L. Severi 1, 06132 Perugia, Italy.ORCID 0000-0001-9257-3997
Graziella MiglioratiPharmacology Division, Department of Medicine and Surgery, University of Perugia, P.le L. Severi 1, 06132 Perugia, Italy.
Simona RonchettiPharmacology Division, Department of Medicine and Surgery, University of Perugia, P.le L. Severi 1, 06132 Perugia, Italy.ORCID 0000-0002-5639-4243
University of Perugia · ITFondazione IRCCS Istituto Nazionale dei Tumori · IT

Funding

Italian Ministry of Education, Universities and Research PRIN 2017B9NCSX
6 · The paper itself

Abstract

Ulcerative colitis (UC) and Crohn's Disease (CD) are chronic relapsing inflammatory diseases that are caused by genetic, environmental, and immune factors. Treatment strategies are currently based on symptomatic control by immunosuppression. The glucocorticoid-induced leucine zipper (GILZ), a mediator of several effects of glucocorticoids, was recently found to be secreted by goblet cells and play a role in inflammatory bowel disease (IBD). This study investigates which genes

Indexed as

Colitis, UlcerativeCrohn DiseaseInflammatory Bowel DiseasesHumansMucin-2Toll-Like Receptor 2Toll-Like Receptor 4Transcription FactorsMUC2 protein, humanMucin-2TLR2 protein, humanTLR4 protein, humanToll-Like Receptor 2Toll-Like Receptor 4Transcription FactorsTSC22D3 protein, humanGILZIBDmucinsTLR

Identifiers

PMID36768553
PMCPMC9917296
OpenAlexW4317931225

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.