Evidence map›Paper›PMID 36768469›Full record

ArticleInternational journal of molecular sciences2023

Insulin Elevates ID2 Expression in Trophoblasts and Aggravates Preeclampsia in Obese ASB4-Null Mice.

Yukako Kayashima, W H Davin Townley-Tilson, Neeta L Vora, Kim Boggess, Jonathon W Homeister, Nobuyo Maeda-Smithies, Feng Li

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Pathophysiology of Maternal Obesity and Hypertension in Pregnancy.Journal of cardiovascular development and disease · 2025
    Review
  4. The Roles of Obesity and ASB4 in Preeclampsia Pathogenesis.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yukako KayashimaDepartment of Pathology and Laboratory Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.
W H Davin Townley-TilsonDepartment of Pathology and Laboratory Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.
Neeta L VoraDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.
Kim BoggessDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.
Jonathon W HomeisterDepartment of Pathology and Laboratory Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.
Nobuyo Maeda-SmithiesDepartment of Pathology and Laboratory Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.
Feng LiDepartment of Pathology and Laboratory Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0002-6779-5077
University of North Carolina at Chapel Hill · US

Funding

UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6M
MODELS FOR STUDYING THE GENETICS OF HYPERTENSIONR01HL049277 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAEDA, NOBUYO · 1992 to 2025
$17.5M
Benefits of nicotinamide in placental development and in preeclamsiaR01HD101485 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, FENG · 2021 to 2025
$2.1M
NHLBI NIH HHS R01 HL049277NICHD NIH HHS R01 HD101485NIDDK NIH HHS P30 DK056350NIH HHS R01HL049277, R01HD101485, P30 DK 034987
6 · The paper itself

Abstract

Obesity is a risk factor for preeclampsia. We investigated how obesity influences preeclampsia in mice lacking ankyrin-repeat-and-SOCS-box-containing-protein 4 (ASB4), which promotes trophoblast differentiation via degrading the inhibitor of DNA-binding protein 2 (ID2).

Indexed as

InsulinPre-EclampsiaAnimalsFemaleHumansInfantInhibitor of Differentiation Protein 2Insulin, Regular, HumanLeptinMaleMiceObesityPlacentaPregnancyTrophoblastsID2 protein, humanInhibitor of Differentiation Protein 2InsulinInsulin, Regular, HumanLeptinID2insulinmaternal obesitypreeclampsiatrophoblast differentiation

Identifiers

PMID36768469
PMCPMC9917068
OpenAlexW4317812643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.