Evidence map›Paper›PMID 36768413›Full record

ArticleInternational journal of molecular sciences2023

Myelin Basic Protein Fragmentation by Engineered Human Proteasomes with Different Catalytic Phenotypes Revealed Direct Peptide Ligands of MS-Associated and Protective HLA Class I Molecules.

George A Saratov, Vasiliy I Vladimirov, Alexey L Novoselov, Rustam H Ziganshin, Guo Chen, Timur N Baymukhametov, Andrey L Konevega, Alexey A Belogurov, Anna A Kudriaeva

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

George A SaratovShemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Vasiliy I VladimirovShemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Alexey L NovoselovShemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.ORCID 0000-0002-6402-6774
Rustam H ZiganshinShemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Guo ChenSchool of Biopharmacy, China Pharmaceutical University, Nanjing 211198, China.
Timur N BaymukhametovNational Research Center, "Kurchatov Institute", 123182 Moscow, Russia.ORCID 0000-0001-8069-9998
Andrey L KonevegaNational Research Center, "Kurchatov Institute", 123182 Moscow, Russia.ORCID 0000-0003-0125-7150
Alexey A BelogurovShemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Anna A KudriaevaShemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.

Funding

Ministry of Science and Higher Education of the Russian Federation 075-15-2020-795
6 · The paper itself

Abstract

Proteasomes exist in mammalian cells in multiple combinatorial variants due to the diverse regulatory particles and exchange of catalytic subunits. Here, using biotin carboxyl carrier domain of transcarboxylase from

Indexed as

Multiple SclerosisMyelin Basic ProteinAnimalsHLA-A AntigensHumansImmunodominant EpitopesLigandsMammalsPeptide FragmentsPeptidesProteasome Endopeptidase ComplexHLA-A AntigensImmunodominant EpitopesLigandsMyelin Basic ProteinPeptide FragmentsPeptidesProteasome Endopeptidase Complexbiotin carboxyl carrier domainHLA class IHTBHIFNγimmunoproteasomemultiple sclerosismyelin basic proteinnegative stain electron microscopyproteasomesodium dodecyl sulfate

Identifiers

PMID36768413
PMCPMC9917034

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.