Evidence map›Paper›PMID 36768379›Full record

ArticleInternational journal of molecular sciences2023

Oleracone F Alleviates Cognitive Impairment and Neuropathology in APPswe/PSEN1dE9 Mice by Reducing the Expression of Vascular Cell Adhesion Molecule and Leukocyte Adhesion to Brain Vascular Endothelial Cells.

Young-Sun Kwon, Jin-Sung Ko, Se-Young Oh, Young Taek Han, Sangmee Ahn Jo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Young-Sun KwonDepartment of Nanobiomedical Science & BK21 Four NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, Republic of Korea.
Jin-Sung KoDepartment of Nanobiomedical Science & BK21 Four NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, Republic of Korea.
Se-Young OhDepartment of Convergence Medicine, Ewha Womans University Mokdong Hospital, Ewha Womans University, Seoul 07985, Republic of Korea.ORCID 0000-0002-9422-1079
Young Taek HanDepartment of Pharmacy, College of Pharmacy, Dankook University, Cheonan 31116, Republic of Korea.
Sangmee Ahn JoDepartment of Nanobiomedical Science & BK21 Four NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, Republic of Korea.

Funding

National Research Foundation of Korea NRF-2019R1A2C1086767
6 · The paper itself

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disease and the blood-brain barrier dysfunction has been suggested as a key pathological feature of the disease. Our research group successfully established a synthetic protocol for oleracones, a novel series of flavonoids isolated from the plant extract of

Indexed as

Alzheimer DiseaseCognitive DysfunctionNeurodegenerative DiseasesAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsBrainEndothelial CellsHumansMiceMice, TransgenicTumor Necrosis Factor-alphaVascular Cell Adhesion Molecule-1Amyloid beta-PeptidesAmyloid beta-Protein PrecursorTumor Necrosis Factor-alphaVascular Cell Adhesion Molecule-1Alzheimer’s diseaseblood–brain barrieroleraconetumor necrosis factor-αvascular cell adhesion molecule-1

Identifiers

PMID36768379
PMCPMC9916962

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.