Evidence map›Paper›PMID 36768365›Full record

ArticleInternational journal of molecular sciences2023

The Variations' in Genes Encoding TIM-3 and Its Ligand, Galectin-9, Influence on ccRCC Risk and Prognosis.

Anna Andrzejczak, Krzysztof Tupikowski, Anna Tomkiewicz, Bartosz Małkiewicz, Kuba Ptaszkowski, Aleksandra Domin, Tomasz Szydełko, Lidia Karabon

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  5. Effect ofInternational journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Anna AndrzejczakLaboratory of Genetics and Epigenetics of Human Diseases, Department of Experimental Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wrocław, Poland.ORCID 0000-0001-6098-7554
Krzysztof TupikowskiSubdivision of Urology, Lower Silesian Center for Oncology, Pulmonology and Hematology, 53-413 Wrocław, Poland.ORCID 0000-0002-0958-7587
Anna TomkiewiczLaboratory of Genetics and Epigenetics of Human Diseases, Department of Experimental Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wrocław, Poland.ORCID 0000-0002-9722-9359
Bartosz MałkiewiczUniversity Center of Excellence in Urology, Department of Minimally Invasive and Robotic Urology, Wroclaw Medical University, 50-556 Wrocław, Poland.ORCID 0000-0002-5933-3753
Kuba PtaszkowskiDepartment of Clinical Biomechanics and Physiotherapy in Motor System Disorders, Wrocław Medical University, 50-556 Wrocław, Poland.ORCID 0000-0002-5690-5226
Aleksandra DominLaboratory of Genetics and Epigenetics of Human Diseases, Department of Experimental Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wrocław, Poland.
Tomasz SzydełkoUniversity Center of Excellence in Urology, Department of Minimally Invasive and Robotic Urology, Wroclaw Medical University, 50-556 Wrocław, Poland.
Lidia KarabonLaboratory of Genetics and Epigenetics of Human Diseases, Department of Experimental Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wrocław, Poland.ORCID 0000-0001-8172-0971
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy · PLWroclaw Medical University · PLLublin Oncology Center · PL

Funding

Foundation of Count Jakub Potocki decision taken by Foundation Board on 16.12.2019Wroclaw Medical University SUBZ.C090.22.057
6 · The paper itself

Abstract

Renal cell cancer is the most common type of kidney cancer in adults, and clear cell renal cell carcinoma (ccRCC) is the most diagnosed type. T cell immunoglobulin and mucin-domain-containing-3 (TIM-3) belongs to immunological checkpoints that are key regulators of the immune response. One of the known TIM-3 ligands is galectin-9 (

Indexed as

Carcinoma, Renal CellKidney NeoplasmsAdultGalectinsGenetic Predisposition to DiseaseHepatitis A Virus Cellular Receptor 2HumansLigandsPolymorphism, Single NucleotideGalectinsHepatitis A Virus Cellular Receptor 2Ligandsclear cell renal cell carcinoma (ccRCC)disease riskgalectin-9 (LGALS9)HAVCR2immunological checkpointoverall survivalsingle-nucleotide gene polymorphism (SNP)TIM-3

Identifiers

PMID36768365
PMCPMC9917084
OpenAlexW4317625844

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.