Evidence map›Paper›PMID 36768302›Full record

ArticleInternational journal of molecular sciences2023

Design and Synthesis of New Quinazolin-4-one Derivatives with Negative mGlu

Katarzyna Kaczorowska, Anna Stankiewicz, Ryszard Bugno, Maria H Paluchowska, Grzegorz Burnat, Piotr Brański, Paulina Cieślik, Joanna M Wierońska, Mariusz Milik, Mateusz Nowak and 8 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Katarzyna KaczorowskaDepartment of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 30-343 Kraków, Poland.ORCID 0000-0001-9221-947X
Anna StankiewiczDepartment of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 30-343 Kraków, Poland.
Ryszard BugnoDepartment of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 30-343 Kraków, Poland.ORCID 0000-0003-3741-674X
Maria H PaluchowskaDepartment of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 30-343 Kraków, Poland.
Grzegorz BurnatDepartment of Neurobiology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 30-343 Kraków, Poland.ORCID 0000-0002-2300-0850
Piotr BrańskiDepartment of Neurobiology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 30-343 Kraków, Poland.
Paulina CieślikDepartment of Neurobiology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 30-343 Kraków, Poland.ORCID 0000-0003-1182-573X
Joanna M WierońskaDepartment of Neurobiology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 30-343 Kraków, Poland.
Mariusz MilikSELVITA S.A., Bobrzyńskiego 14, 30-348 Kraków, Poland.
Mateusz NowakSELVITA S.A., Bobrzyńskiego 14, 30-348 Kraków, Poland.
Agnieszka PrzybyłowiczSELVITA S.A., Bobrzyńskiego 14, 30-348 Kraków, Poland.
Aneta KoziołDepartment of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 30-343 Kraków, Poland.
Agata HogendorfDepartment of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 30-343 Kraków, Poland.ORCID 0000-0003-4889-1001
Adam S HogendorfDepartment of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 30-343 Kraków, Poland.ORCID 0000-0003-3311-3266
Justyna Kalinowska-TłuścikDepartment of Crystal Chemistry and Crystal Physic, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Kraków, Poland.ORCID 0000-0001-7714-1651
Beata DuszyńskaDepartment of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 30-343 Kraków, Poland.
Andrzej PilcDepartment of Neurobiology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 30-343 Kraków, Poland.ORCID 0000-0002-4045-0597
Andrzej J BojarskiDepartment of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 30-343 Kraków, Poland.ORCID 0000-0003-1417-6333
Maj Institute of Pharmacology · PLJagiellonian University · PL

Funding

Polish National Centre for Research and Development PBS1/B7/8/2012
6 · The paper itself

Abstract

Following the glutamatergic theory of schizophrenia and based on our previous study regarding the antipsychotic-like activity of mGlu

Indexed as

Antipsychotic AgentsQuinazolinonesReceptors, Metabotropic GlutamateSchizophreniaAnimalsDizocilpine MaleateDrug DesignHumans4-hydroxyquinazolineAntipsychotic AgentsDizocilpine MaleateQuinazolinonesReceptors, Metabotropic GlutamateantipsychoticmGlu7 metabotropic glutamate receptor 7negative allosteric modulators (NAMs)

Identifiers

PMID36768302
PMCPMC9916658
OpenAlexW4317508629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.